The Biological Functions and Clinical Applications of Integrins in Cancers

Overview

Journal Front Pharmacol

Date 2020 Oct 12

PMID 33041823

Citations 55

Authors

Chao-Yue Su

Jing-Quan Li

Ling-Ling Zhang

Hui Wang

Feng-Hua Wang

Yi-Wen Tao

Yu-Qing Wang

Qiao-Ru Guo

Jia-Jun Li

Yun Liu

Yan-Yan Yan

Jian-Ye Zhang

Affiliations

Soon will be listed here.

Abstract

Integrins are the adhesion molecules and receptors of extracellular matrix (ECM). They mediate the interactions between cells-cells and cells-ECM. The crosstalk between cancer cells and their microenvironment triggers a variety of critical signaling cues and promotes the malignant phenotype of cancer. As a type of transmembrane protein, integrin-mediated cell adhesion is essential in regulating various biological functions of cancer cells. Recent evidence has shown that integrins present on tumor cells or tumor-associated stromal cells are involved in ECM remodeling, and as mechanotransducers sensing changes in the biophysical properties of the ECM, which contribute to cancer metastasis, stemness and drug resistance. In this review, we outline the mechanism of integrin-mediated effects on biological changes of cancers and highlight the current status of clinical treatments by targeting integrins.

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