TRPV Channels in Osteoarthritis: A Comprehensive Review

Overview

Journal Biomolecules

Publisher MDPI

Specialties Biochemistry
Molecular Biology

Date 2024 Mar 28

PMID 38540712

Authors

Changshun Chen

Fei Yang

Rongjin Chen

Chenhui Yang

Hefang Xiao

Bin Geng

Yayi Xia

Affiliations

Soon will be listed here.

Abstract

Osteoarthritis (OA) is a debilitating joint disorder that affects millions of people worldwide. Despite its prevalence, our understanding of the underlying mechanisms remains incomplete. In recent years, transient receptor potential vanilloid (TRPV) channels have emerged as key players in OA pathogenesis. This review provides an in-depth exploration of the role of the TRPV pathway in OA, encompassing its involvement in pain perception, inflammation, and mechanotransduction. Furthermore, we discuss the latest research findings, potential therapeutic strategies, and future directions in the field, shedding light on the multifaceted nature of TRPV channels in OA.

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