» Articles » PMID: 38539598

The Constrained Disorder Principle May Account for Consciousness

Overview
Journal Brain Sci
Publisher MDPI
Date 2024 Mar 28
PMID 38539598
Authors
Affiliations
Soon will be listed here.
Abstract

There is still controversy surrounding the definition and mechanisms of consciousness. The constrained disorder principle (CDP) defines complex systems by their dynamic borders, limiting their inherent disorder. In line with the CDP, the brain exhibits a disorder bounded by dynamic borders essential for proper function, efficient energy use, and life support under continuous perturbations. The brain's inherent variability contributes to its adaptability and flexibility. Neuronal signal variability challenges the association of brain structures with consciousness and methods for assessing consciousness. The present paper discusses some theories about consciousness, emphasizing their failure to explain the brain's variability. This paper describes how the CDP accounts for consciousness's variability, complexity, entropy, and uncertainty. Using newly developed second-generation artificial intelligence systems, we describe how CDP-based platforms may improve disorders of consciousness (DoC) by accounting for consciousness variability, complexity, entropy, and uncertainty. This platform could be used to improve response to current interventions and develop new therapeutic regimens for patients with DoC in future studies.

Citing Articles

Inter-organ correlations in inflammation regulation: a novel biological paradigm in a murine model.

Shabat Y, Rotnemer-Golinkin D, Zolotarov L, Ilan Y J Med Life. 2025; 18(1):67-72.

PMID: 40071160 PMC: 11891616. DOI: 10.25122/jml-2024-0246.


The Co-Piloting Model for Using Artificial Intelligence Systems in Medicine: Implementing the Constrained-Disorder-Principle-Based Second-Generation System.

Ilan Y Bioengineering (Basel). 2024; 11(11).

PMID: 39593770 PMC: 11592301. DOI: 10.3390/bioengineering11111111.


Using the Constrained Disorder Principle to Navigate Uncertainties in Biology and Medicine: Refining Fuzzy Algorithms.

Ilan Y Biology (Basel). 2024; 13(10).

PMID: 39452139 PMC: 11505099. DOI: 10.3390/biology13100830.


Improving the response to lenvatinib in partial responders using a Constrained-Disorder-Principle-based second-generation artificial intelligence-therapeutic regimen: a proof-of-concept open-labeled clinical trial.

Sigawi T, Gelman R, Maimon O, Yossef A, Hemed N, Agus S Front Oncol. 2024; 14:1426426.

PMID: 39139285 PMC: 11319816. DOI: 10.3389/fonc.2024.1426426.

References
1.
Fagerholm E, Scott G, Shew W, Song C, Leech R, Knopfel T . Cortical Entropy, Mutual Information and Scale-Free Dynamics in Waking Mice. Cereb Cortex. 2016; 26(10):3945-52. PMC: 5028006. DOI: 10.1093/cercor/bhw200. View

2.
Scott G, Carhart-Harris R . Psychedelics as a treatment for disorders of consciousness. Neurosci Conscious. 2019; 2019(1):niz003. PMC: 6475593. DOI: 10.1093/nc/niz003. View

3.
Block N . Consciousness, accessibility, and the mesh between psychology and neuroscience. Behav Brain Sci. 2008; 30(5-6):481-99. DOI: 10.1017/S0140525X07002786. View

4.
Sigawi T, Ilan Y . Using Constrained-Disorder Principle-Based Systems to Improve the Performance of Digital Twins in Biological Systems. Biomimetics (Basel). 2023; 8(4). PMC: 10452845. DOI: 10.3390/biomimetics8040359. View

5.
Aamodt A, Nilsen A, Markhus R, Kusztor A, HasanzadehMoghadam F, Kauppi N . EEG Lempel-Ziv complexity varies with sleep stage, but does not seem to track dream experience. Front Hum Neurosci. 2023; 16:987714. PMC: 9871639. DOI: 10.3389/fnhum.2022.987714. View