CVRmap-a Complete Cerebrovascular Reactivity Mapping Post-processing BIDS Toolbox

Overview

Journal Sci Rep

Specialty Science

Date 2024 Mar 28

PMID 38538633

Authors

A Rovai

V Lolli

N Trotta

S Goldman

X De Tiege

Affiliations

Soon will be listed here.

Abstract

Cerebrovascular Reactivity (CVR) refers to the ability of cerebral blood vessels to dilate or constrict under the effect of vasoactive substances and can be estimated using functional Magnetic Resonance Imaging (fMRI). Computation of CVR maps is relevant in various brain diseases and requires specialized data processing. We introduce CVRmap, an opensource software that automates the computation of CVR map. The toolbox complies with the Brain Imaging Data Structure (BIDS) standards.

Citing Articles

CVRmap-a complete cerebrovascular reactivity mapping post-processing BIDS toolbox.

Rovai A, Lolli V, Trotta N, Goldman S, De Tiege X Sci Rep. 2024; 14(1):7252.

PMID: 38538633 PMC: 10973431. DOI: 10.1038/s41598-024-57572-3.

References

Chen J, Pike G . BOLD-specific cerebral blood volume and blood flow changes during neuronal activation in humans. NMR Biomed. 2009; 22(10):1054-62. DOI: 10.1002/nbm.1411. View

Donahue M, Strother M, Lindsey K, Hocke L, Tong Y, Frederick B . Time delay processing of hypercapnic fMRI allows quantitative parameterization of cerebrovascular reactivity and blood flow delays. J Cereb Blood Flow Metab. 2015; 36(10):1767-1779. PMC: 5076782. DOI: 10.1177/0271678X15608643. View

Cohen A, Wang Y . Improving the Assessment of Breath-Holding Induced Cerebral Vascular Reactivity Using a Multiband Multi-echo ASL/BOLD Sequence. Sci Rep. 2019; 9(1):5079. PMC: 6434035. DOI: 10.1038/s41598-019-41199-w. View

Tong Y, Bergethon P, Frederick B . An improved method for mapping cerebrovascular reserve using concurrent fMRI and near-infrared spectroscopy with Regressor Interpolation at Progressive Time Delays (RIPTiDe). Neuroimage. 2011; 56(4):2047-57. PMC: 3134125. DOI: 10.1016/j.neuroimage.2011.03.071. View

Cohen A, Jagra A, Visser N, Yang B, Fernandez B, Banerjee S . Improving the Breath-Holding CVR Measurement Using the Multiband Multi-Echo EPI Sequence. Front Physiol. 2021; 12:619714. PMC: 7953053. DOI: 10.3389/fphys.2021.619714. View

Agarwal S, Sair H, Pillai J . The Problem of Neurovascular Uncoupling. Neuroimaging Clin N Am. 2020; 31(1):53-67. DOI: 10.1016/j.nic.2020.09.003. View

Grubb Jr R, Raichle M, Eichling J, Ter-Pogossian M . The effects of changes in PaCO2 on cerebral blood volume, blood flow, and vascular mean transit time. Stroke. 1974; 5(5):630-9. DOI: 10.1161/01.str.5.5.630. View

Liu P, Baker Z, Li Y, Li Y, Xu J, Park D . CVR-MRICloud: An online processing tool for CO2-inhalation and resting-state cerebrovascular reactivity (CVR) MRI data. PLoS One. 2022; 17(9):e0274220. PMC: 9518872. DOI: 10.1371/journal.pone.0274220. View

Bhogal A . Medullary vein architecture modulates the white matter BOLD cerebrovascular reactivity signal response to CO: Observations from high-resolution T2* weighted imaging at 7T. Neuroimage. 2021; 245:118771. DOI: 10.1016/j.neuroimage.2021.118771. View

10.

Erdogan S, Tong Y, Hocke L, Lindsey K, Frederick B . Correcting for Blood Arrival Time in Global Mean Regression Enhances Functional Connectivity Analysis of Resting State fMRI-BOLD Signals. Front Hum Neurosci. 2016; 10:311. PMC: 4923135. DOI: 10.3389/fnhum.2016.00311. View

11.

Lu H, Xu F, Rodrigue K, Kennedy K, Cheng Y, Flicker B . Alterations in cerebral metabolic rate and blood supply across the adult lifespan. Cereb Cortex. 2010; 21(6):1426-34. PMC: 3097991. DOI: 10.1093/cercor/bhq224. View

12.

Liu P, De Vis J, Lu H . Cerebrovascular reactivity (CVR) MRI with CO2 challenge: A technical review. Neuroimage. 2018; 187:104-115. PMC: 6150860. DOI: 10.1016/j.neuroimage.2018.03.047. View

13.

Leung T, Tachtsidis I, Tisdall M, Pritchard C, Smith M, Elwell C . Estimating a modified Grubb's exponent in healthy human brains with near infrared spectroscopy and transcranial Doppler. Physiol Meas. 2008; 30(1):1-12. DOI: 10.1088/0967-3334/30/1/001. View

14.

Champagne A, Bhogal A, Coverdale N, Mark C, Cook D . A novel perspective to calibrate temporal delays in cerebrovascular reactivity using hypercapnic and hyperoxic respiratory challenges. Neuroimage. 2017; 187:154-165. DOI: 10.1016/j.neuroimage.2017.11.044. View

15.

Sleight E, Stringer M, Marshall I, Wardlaw J, Thrippleton M . Cerebrovascular Reactivity Measurement Using Magnetic Resonance Imaging: A Systematic Review. Front Physiol. 2021; 12:643468. PMC: 7947694. DOI: 10.3389/fphys.2021.643468. View

16.

Esteban O, Ciric R, Finc K, Blair R, Markiewicz C, Moodie C . Analysis of task-based functional MRI data preprocessed with fMRIPrep. Nat Protoc. 2020; 15(7):2186-2202. PMC: 7404612. DOI: 10.1038/s41596-020-0327-3. View

17.

Lu H, Liu P, Yezhuvath U, Cheng Y, Marshall O, Ge Y . MRI mapping of cerebrovascular reactivity via gas inhalation challenges. J Vis Exp. 2014; (94). PMC: 4396915. DOI: 10.3791/52306. View

18.

Poublanc J, Crawley A, Sobczyk O, Montandon G, Sam K, Mandell D . Measuring cerebrovascular reactivity: the dynamic response to a step hypercapnic stimulus. J Cereb Blood Flow Metab. 2015; 35(11):1746-56. PMC: 4635229. DOI: 10.1038/jcbfm.2015.114. View

19.

Esteban O, Markiewicz C, Blair R, Moodie C, Isik A, Erramuzpe A . fMRIPrep: a robust preprocessing pipeline for functional MRI. Nat Methods. 2018; 16(1):111-116. PMC: 6319393. DOI: 10.1038/s41592-018-0235-4. View

20.

Wise R, Pattinson K, Bulte D, Chiarelli P, Mayhew S, Balanos G . Dynamic forcing of end-tidal carbon dioxide and oxygen applied to functional magnetic resonance imaging. J Cereb Blood Flow Metab. 2007; 27(8):1521-32. DOI: 10.1038/sj.jcbfm.9600465. View