Plasma NEDD9 is Increased Following SARS-CoV-2 Infection and Associates with Indices of Pulmonary Vascular Dysfunction

Overview

Journal Pulm Circ

Publisher Wiley

Specialty Pulmonary Medicine

Date 2024 Mar 19

PMID 38500738

Authors

George A Alba

Iris Y Zhou

Molly Mascia

Michael Magaletta

Jehan W Alladina

Francesca L Giacona

Leo C Ginns

Peter Caravan

Bradley A Maron

Sydney B Montesi

Affiliations

Soon will be listed here.

Abstract

Compared to healthy volunteers, participants with post-acute sequelae of SARS-CoV-2 infection (PASC) demonstrated increased plasma levels of the prothrombotic protein NEDD9, which associated inversely with indices of pulmonary vascular function. This suggests persistent pulmonary vascular dysfunction may play a role in the pathobiology of PASC.

Citing Articles

Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis.

Heydemann L, Ciurkiewicz M, Stork T, Zdora I, Hulskotter K, Gregor K Nat Commun. 2025; 16(1):2080.

PMID: 40021627 PMC: 11871369. DOI: 10.1038/s41467-025-57267-x.

Mechanisms of Pulmonary Vasculopathy in Acute and Long-Term COVID-19: A Review.

Riou M, Coste F, Meyer A, Enache I, Talha S, Charloux A Int J Mol Sci. 2024; 25(9).

PMID: 38732160 PMC: 11084496. DOI: 10.3390/ijms25094941.

Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction.

Alba G, Zhou I, Mascia M, Magaletta M, Alladina J, Giacona F Pulm Circ. 2024; 14(1):e12356.

PMID: 38500738 PMC: 10946282. DOI: 10.1002/pul2.12356.

References

Alba G, Samokhin A, Wang R, Wertheim B, Haley K, Padera R . Pulmonary endothelial NEDD9 and the prothrombotic pathophenotype of acute respiratory distress syndrome due to SARS-CoV-2 infection. Pulm Circ. 2022; 12(2):e12071. PMC: 9111030. DOI: 10.1002/pul2.12071. View

Ackermann M, Verleden S, Kuehnel M, Haverich A, Welte T, Laenger F . Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med. 2020; 383(2):120-128. PMC: 7412750. DOI: 10.1056/NEJMoa2015432. View

Mahler D, Wells C . Evaluation of clinical methods for rating dyspnea. Chest. 1988; 93(3):580-6. DOI: 10.1378/chest.93.3.580. View

Soriano J, Murthy S, Marshall J, Relan P, Diaz J . A clinical case definition of post-COVID-19 condition by a Delphi consensus. Lancet Infect Dis. 2021; 22(4):e102-e107. PMC: 8691845. DOI: 10.1016/S1473-3099(21)00703-9. View

Alba G, Samokhin A, Wang R, Zhang Y, Wertheim B, Arons E . NEDD9 Is a Novel and Modifiable Mediator of Platelet-Endothelial Adhesion in the Pulmonary Circulation. Am J Respir Crit Care Med. 2021; 203(12):1533-1545. PMC: 8483217. DOI: 10.1164/rccm.202003-0719OC. View

Talla A, Vasaikar S, Szeto G, Lemos M, Czartoski J, MacMillan H . Persistent serum protein signatures define an inflammatory subcategory of long COVID. Nat Commun. 2023; 14(1):3417. PMC: 10252177. DOI: 10.1038/s41467-023-38682-4. View

Su Y, Yuan D, Chen D, Ng R, Wang K, Choi J . Multiple early factors anticipate post-acute COVID-19 sequelae. Cell. 2022; 185(5):881-895.e20. PMC: 8786632. DOI: 10.1016/j.cell.2022.01.014. View

Espin E, Yang C, Shannon C, Assadian S, He D, Tebbutt S . Cellular and molecular biomarkers of long COVID: a scoping review. EBioMedicine. 2023; 91:104552. PMC: 10082390. DOI: 10.1016/j.ebiom.2023.104552. View

Weatherley N, Eaden J, Hughes P, Austin M, Smith L, Bray J . Quantification of pulmonary perfusion in idiopathic pulmonary fibrosis with first pass dynamic contrast-enhanced perfusion MRI. Thorax. 2020; 76(2):144-151. PMC: 7815896. DOI: 10.1136/thoraxjnl-2019-214375. View

10.

Nikonova A, Gaponova A, Kudinov A, Golemis E . CAS proteins in health and disease: an update. IUBMB Life. 2014; 66(6):387-95. PMC: 4111207. DOI: 10.1002/iub.1282. View

11.

Alba G, Zhou I, Mascia M, Magaletta M, Alladina J, Giacona F . Plasma NEDD9 is increased following SARS-CoV-2 infection and associates with indices of pulmonary vascular dysfunction. Pulm Circ. 2024; 14(1):e12356. PMC: 10946282. DOI: 10.1002/pul2.12356. View

12.

Zhou I, Mascia M, Alba G, Magaletta M, Ginns L, Caravan P . Dynamic Contrast-enhanced MRI Demonstrates Pulmonary Microvascular Abnormalities Months After SARS-CoV-2 Infection. Am J Respir Crit Care Med. 2023; 207(12):1636-1639. PMC: 10273117. DOI: 10.1164/rccm.202210-1884LE. View

13.

Izquierdo-Garcia D, Desogere P, Philip A, Mekkaoui C, Weiner R, Catalano O . Detection and Characterization of Thrombosis in Humans Using Fibrin-Targeted Positron Emission Tomography and Magnetic Resonance. JACC Cardiovasc Imaging. 2021; 15(3):504-515. PMC: 8917974. DOI: 10.1016/j.jcmg.2021.08.009. View

14.

Villalba J, Hilburn C, Garlin M, Elliott G, Li Y, Kunitoki K . Vasculopathy and Increased Vascular Congestion in Fatal COVID-19 and Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2022; 206(7):857-873. PMC: 9799276. DOI: 10.1164/rccm.202109-2150OC. View

15.

Montesi S, Zhou I, Liang L, Digumarthy S, Mercaldo S, Mercaldo N . Dynamic contrast-enhanced magnetic resonance imaging of the lung reveals important pathobiology in idiopathic pulmonary fibrosis. ERJ Open Res. 2021; 7(4). PMC: 8573229. DOI: 10.1183/23120541.00907-2020. View

16.

Sherif Z, Gomez C, Connors T, Henrich T, Reeves W . Pathogenic mechanisms of post-acute sequelae of SARS-CoV-2 infection (PASC). Elife. 2023; 12. PMC: 10032659. DOI: 10.7554/eLife.86002. View

17.

Davis H, McCorkell L, Vogel J, Topol E . Long COVID: major findings, mechanisms and recommendations. Nat Rev Microbiol. 2023; 21(3):133-146. PMC: 9839201. DOI: 10.1038/s41579-022-00846-2. View

18.

Ahamed J, Laurence J . Long COVID endotheliopathy: hypothesized mechanisms and potential therapeutic approaches. J Clin Invest. 2022; 132(15). PMC: 9337829. DOI: 10.1172/JCI161167. View

19.

Samokhin A, Hsu S, Yu P, Waxman A, Alba G, Wertheim B . Circulating NEDD9 is increased in pulmonary arterial hypertension: A multicenter, retrospective analysis. J Heart Lung Transplant. 2020; 39(4):289-299. PMC: 7605895. DOI: 10.1016/j.healun.2019.12.002. View