Prognostic Value of Tumor‑associated CD177 Neutrophils in Lung Adenocarcinoma

Overview

Journal Oncol Lett

Specialty Oncology

Date 2024 Mar 18

PMID 38495836

Authors

Jinhua Zhou

Qingxia Xu

Huan Liu

Jianlong Miao

Cuixia Bian

Yutao Wei

Wei Wang

Shulong Jiang

Affiliations

Soon will be listed here.

Abstract

The aim of the present study was to detect CD177 neutrophils in tumor tissues and analyze their association with the clinical characteristics and prognosis of patients with lung adenocarcinoma (LUAD). Immunohistochemistry was used to detect CD177 neutrophils in tumors and adjacent tissues of 16 patients with LUAD who underwent curative surgical resection. A total of 120 patients with LUAD were recruited, and their clinical data were collected; survival follow-up was performed. CD177 neutrophils in tumor tissues were detected via immunohistochemistry, and the association between CD177 neutrophils and clinical characteristics was analyzed. The density of CD177 neutrophils in tumor tissues and adjacent tissues of patients with LUAD was analyzed using t-test, and the association between CD177 neutrophils and clinical characteristics was analyzed through the Chi-square test. Survival was calculated using the Kaplan-Meier survival rate curve. Finally, the association between these indicators and the survival of LUAD patients was evaluated using Cox regression analysis. CD177 neutrophil infiltration was significantly higher in LUAD tumor tissues, and the high density of CD177 neutrophils was associated with the clinical characteristics of TNM stage, tumor differentiation and poor progression-free and overall survival in LUAD. In conclusion, tumor-associated CD177 neutrophils associated with malignant progression and poor prognosis may be independent and unfavorable prognostic biomarkers for LUAD.

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References

Capone M, Giannarelli D, Mallardo D, Madonna G, Festino L, Grimaldi A . Baseline neutrophil-to-lymphocyte ratio (NLR) and derived NLR could predict overall survival in patients with advanced melanoma treated with nivolumab. J Immunother Cancer. 2018; 6(1):74. PMC: 6048712. DOI: 10.1186/s40425-018-0383-1. View

Dumitru C, Lang S, Brandau S . Modulation of neutrophil granulocytes in the tumor microenvironment: mechanisms and consequences for tumor progression. Semin Cancer Biol. 2013; 23(3):141-8. DOI: 10.1016/j.semcancer.2013.02.005. View

Svaton M, Blazek J, Krakorova G, Buresova M, Teufelova Z, Vodicka J . Laboratory Parameters are Possible Prognostic Markers in Patients with Advanced-stage NSCLC Treated with Bevacizumab plus Chemotherapy. J Cancer. 2021; 12(19):5753-5759. PMC: 8408121. DOI: 10.7150/jca.58851. View

Rakaee M, Busund L, Paulsen E, Richardsen E, Al-Saad S, Andersen S . Prognostic effect of intratumoral neutrophils across histological subtypes of non-small cell lung cancer. Oncotarget. 2016; 7(44):72184-72196. PMC: 5342153. DOI: 10.18632/oncotarget.12360. View

Sebastian N, Raj R, Prasad R, Barney C, Brownstein J, Grecula J . Association of Pre- and Posttreatment Neutrophil-Lymphocyte Ratio With Recurrence and Mortality in Locally Advanced Non-Small Cell Lung Cancer. Front Oncol. 2020; 10:598873. PMC: 7676908. DOI: 10.3389/fonc.2020.598873. View

Zhang Y, Lu J, Du Y, Feng C, Wang L, Chen M . Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in gastric cancer. Medicine (Baltimore). 2018; 97(12):e0144. PMC: 5895303. DOI: 10.1097/MD.0000000000010144. View

Wang Y, Fang T, Huang L, Wang H, Zhang L, Wang Z . Neutrophils infiltrating pancreatic ductal adenocarcinoma indicate higher malignancy and worse prognosis. Biochem Biophys Res Commun. 2018; 501(1):313-319. DOI: 10.1016/j.bbrc.2018.05.024. View

Carus A, Ladekarl M, Hager H, Pilegaard H, Nielsen P, Donskov F . Tumor-associated neutrophils and macrophages in non-small cell lung cancer: no immediate impact on patient outcome. Lung Cancer. 2013; 81(1):130-7. DOI: 10.1016/j.lungcan.2013.03.003. View

Shaul M, Fridlender Z . Tumour-associated neutrophils in patients with cancer. Nat Rev Clin Oncol. 2019; 16(10):601-620. DOI: 10.1038/s41571-019-0222-4. View

10.

Orozco-Morales M, Soca-Chafre G, Barrios-Bernal P, Hernandez-Pedro N, Arrieta O . Interplay between Cellular and Molecular Inflammatory Mediators in Lung Cancer. Mediators Inflamm. 2016; 2016:3494608. PMC: 4749813. DOI: 10.1155/2016/3494608. View

11.

Albrengues J, Shields M, Ng D, Park C, Ambrico A, Poindexter M . Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice. Science. 2018; 361(6409). PMC: 6777850. DOI: 10.1126/science.aao4227. View

12.

Fang L, Izumi K, Lai K, Liang L, Li L, Miyamoto H . Infiltrating macrophages promote prostate tumorigenesis via modulating androgen receptor-mediated CCL4-STAT3 signaling. Cancer Res. 2013; 73(18):5633-46. PMC: 3833080. DOI: 10.1158/0008-5472.CAN-12-3228. View

13.

Zhou G, Peng K, Song Y, Yang W, Shu W, Yu T . CD177+ neutrophils suppress epithelial cell tumourigenesis in colitis-associated cancer and predict good prognosis in colorectal cancer. Carcinogenesis. 2017; 39(2):272-282. DOI: 10.1093/carcin/bgx142. View

14.

Galdiero M, Bianchi P, Grizzi F, Caro G, Basso G, Ponzetta A . Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer. Int J Cancer. 2016; 139(2):446-56. DOI: 10.1002/ijc.30076. View

15.

Yang J, Deng M, Bi M, Wang Y, Qiao X, Zhang S . Prognostic values of inflammatory indexes in bevacizumab-treated patients with advanced non-small-cell lung cancer. Future Sci OA. 2022; 8(5):FSO798. PMC: 9136631. DOI: 10.2144/fsoa-2021-0162. View

16.

Punjabi A, Barrett E, Cheng A, Mulla A, Walls G, Johnston D . Neutrophil-Lymphocyte Ratio and Absolute Lymphocyte Count as Prognostic Markers in Patients Treated with Curative-intent Radiotherapy for Non-small Cell Lung Cancer. Clin Oncol (R Coll Radiol). 2021; 33(8):e331-e338. DOI: 10.1016/j.clon.2021.03.019. View

17.

Eruslanov E, Bhojnagarwala P, Quatromoni J, Stephen T, Ranganathan A, Deshpande C . Tumor-associated neutrophils stimulate T cell responses in early-stage human lung cancer. J Clin Invest. 2014; 124(12):5466-80. PMC: 4348966. DOI: 10.1172/JCI77053. View

18.

Wang J, Jia Y, Wang N, Zhang X, Tan B, Zhang G . The clinical significance of tumor-infiltrating neutrophils and neutrophil-to-CD8+ lymphocyte ratio in patients with resectable esophageal squamous cell carcinoma. J Transl Med. 2014; 12:7. PMC: 3895663. DOI: 10.1186/1479-5876-12-7. View

19.

Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M . Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2014; 136(5):E359-86. DOI: 10.1002/ijc.29210. View

20.

Toyoda T, Tsukamoto T, Yamamoto M, Ban H, Saito N, Takasu S . Gene expression analysis of a Helicobacter pylori-infected and high-salt diet-treated mouse gastric tumor model: identification of CD177 as a novel prognostic factor in patients with gastric cancer. BMC Gastroenterol. 2013; 13:122. PMC: 3734037. DOI: 10.1186/1471-230X-13-122. View