Prognostic Values of Inflammatory Indexes in Bevacizumab-treated Patients with Advanced Non-small-cell Lung Cancer

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2022 Jun 6

PMID 35662746

Authors

Jingru Yang

Mingliang Deng

Minghong Bi

Yaping Wang

Xuxu Qiao

Shanshan Zhang

Affiliations

Soon will be listed here.

Abstract

Purpose: Inflammatory indexes, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and lymphocyte-to-monocyte ratio (LMR), have been confirmed as prognostic factors in multiple manigances. However, the prognostic value of these parameters in bevacizumab-treated non-small-cell lung cancer (NSCLC) is still not clear.

Methods: We retrospectively studied 119 patients with advanced NSCLC who received bevacizumab treatment. The associations of pretreatment NLR, PLR, SII and LMR with progression-free survival (PFS) and overall survival (OS) were analyzed.

Results & Conclusion: The median PFS and OS of patients with high baseline NLR, PLR and SII and low LMR were significantly decreased than those of patients with low baseline NLR, PLR and SII and high LMR. Multivariable analysis indicated that high baseline SII was independently related with inferior prognosis, and baseline LMR was an independent predictor for OS.

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References

Rossi S, Basso M, Strippoli A, Schinzari G, DArgento E, Larocca M . Are Markers of Systemic Inflammation Good Prognostic Indicators in Colorectal Cancer?. Clin Colorectal Cancer. 2017; 16(4):264-274. DOI: 10.1016/j.clcc.2017.03.015. View

Mandaliya H, Jones M, Oldmeadow C, Nordman I . Prognostic biomarkers in stage IV non-small cell lung cancer (NSCLC): neutrophil to lymphocyte ratio (NLR), lymphocyte to monocyte ratio (LMR), platelet to lymphocyte ratio (PLR) and advanced lung cancer inflammation index (ALI). Transl Lung Cancer Res. 2020; 8(6):886-894. PMC: 6976360. DOI: 10.21037/tlcr.2019.11.16. View

Yang Z, Zhang J, Lu Y, Xu Q, Tang B, Wang Q . Aspartate aminotransferase-lymphocyte ratio index and systemic immune-inflammation index predict overall survival in HBV-related hepatocellular carcinoma patients after transcatheter arterial chemoembolization. Oncotarget. 2015; 6(40):43090-8. PMC: 4767493. DOI: 10.18632/oncotarget.5719. View

Salati M, Filippi R, Vivaldi C, Caputo F, Leone F, Salani F . The prognostic nutritional index predicts survival and response to first-line chemotherapy in advanced biliary cancer. Liver Int. 2019; 40(3):704-711. DOI: 10.1111/liv.14314. View

Zhang J, Zhang H, Li J, Shao X, Zhang C . The elevated NLR, PLR and PLT may predict the prognosis of patients with colorectal cancer: a systematic review and meta-analysis. Oncotarget. 2017; 8(40):68837-68846. PMC: 5620300. DOI: 10.18632/oncotarget.18575. View

Bade B, Dela Cruz C . Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med. 2020; 41(1):1-24. DOI: 10.1016/j.ccm.2019.10.001. View

Miyamoto R, Inagawa S, Sano N, Tadano S, Adachi S, Yamamoto M . The neutrophil-to-lymphocyte ratio (NLR) predicts short-term and long-term outcomes in gastric cancer patients. Eur J Surg Oncol. 2018; 44(5):607-612. DOI: 10.1016/j.ejso.2018.02.003. View

Trinh H, Dzul S, Hyder J, Jang H, Kim S, Flowers J . Prognostic value of changes in neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR) for patients with cervical cancer undergoing definitive chemoradiotherapy (dCRT). Clin Chim Acta. 2020; 510:711-716. DOI: 10.1016/j.cca.2020.09.008. View

Bremnes R, Busund L, Kilvaer T, Andersen S, Richardsen E, Paulsen E . The Role of Tumor-Infiltrating Lymphocytes in Development, Progression, and Prognosis of Non-Small Cell Lung Cancer. J Thorac Oncol. 2016; 11(6):789-800. DOI: 10.1016/j.jtho.2016.01.015. View

10.

Li B, Wang S, Li C, Guo M, Xu Y, Sun X . The Kinetic Changes of Systemic Inflammatory Factors during Bevacizumab Treatment and Its Prognostic Role in Advanced Non-small Cell Lung Cancer Patients. J Cancer. 2019; 10(21):5082-5089. PMC: 6775608. DOI: 10.7150/jca.30478. View

11.

Stone R, Nick A, McNeish I, Balkwill F, Han H, Bottsford-Miller J . Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012; 366(7):610-8. PMC: 3296780. DOI: 10.1056/NEJMoa1110352. View

12.

Passardi A, Scarpi E, Cavanna L, DallAgata M, Tassinari D, Leo S . Inflammatory indexes as predictors of prognosis and bevacizumab efficacy in patients with metastatic colorectal cancer. Oncotarget. 2016; 7(22):33210-9. PMC: 5078087. DOI: 10.18632/oncotarget.8901. View

13.

Rahma O, Hodi F . The Intersection between Tumor Angiogenesis and Immune Suppression. Clin Cancer Res. 2019; 25(18):5449-5457. DOI: 10.1158/1078-0432.CCR-18-1543. View

14.

Liu Z, Zeng T, Zhou X, Ren Y, Zhang L, Zhang X . Neutrophil-lymphocyte ratio as a prognostic marker for chemotherapy in advanced lung cancer. Int J Biol Markers. 2016; 31(4):e395-e401. DOI: 10.5301/jbm.5000222. View

15.

Diakos C, Charles K, McMillan D, Clarke S . Cancer-related inflammation and treatment effectiveness. Lancet Oncol. 2014; 15(11):e493-503. DOI: 10.1016/S1470-2045(14)70263-3. View

16.

Qian B, Pollard J . Macrophage diversity enhances tumor progression and metastasis. Cell. 2010; 141(1):39-51. PMC: 4994190. DOI: 10.1016/j.cell.2010.03.014. View

17.

Bottsford-Miller J, Coleman R, Sood A . Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies. J Clin Oncol. 2012; 30(32):4026-34. PMC: 3488272. DOI: 10.1200/JCO.2012.41.9242. View

18.

Koehne P, Willam C, Strauss E, Schindler R, Eckardt K, Buhrer C . Lack of hypoxic stimulation of VEGF secretion from neutrophils and platelets. Am J Physiol Heart Circ Physiol. 2000; 279(2):H817-24. DOI: 10.1152/ajpheart.2000.279.2.H817. View

19.

Zikos T, Donnenberg A, Landreneau R, Luketich J, Donnenberg V . Lung T-cell subset composition at the time of surgical resection is a prognostic indicator in non-small cell lung cancer. Cancer Immunol Immunother. 2011; 60(6):819-27. PMC: 4154502. DOI: 10.1007/s00262-011-0996-4. View

20.

Farhood B, Najafi M, Mortezaee K . CD8 cytotoxic T lymphocytes in cancer immunotherapy: A review. J Cell Physiol. 2018; 234(6):8509-8521. DOI: 10.1002/jcp.27782. View