CBX2 Deletion Suppresses Growth and Metastasis of Colorectal Cancer by Mettl3-p38/ERK MAPK Signalling Pathway

Overview

Journal J Cancer

Specialty Oncology

Date 2024 Mar 18

PMID 38495501

Authors

Rui Sun

Xucan Tu

Shixin Chan

Xu Wang

Yizhong Ji

Zhenglin Wang

Zhen Yu

Xiaomin Zuo

Qing Zhang

Jiajie Chen

Qijun Han

Ming Wang

Hu Zhao

Huabing Zhang

Wei Chen

Affiliations

Soon will be listed here.

Abstract

Colorectal cancer (CRC) seriously endangers human health owing to its high morbidity and mortality. Previous studies have suggested that high expression of CBX2 may be associated with poor prognosis in CRC patients. However, its functional role in CRC remains to be elucidated. Herein, we found that CBX2 overexpression in colorectal cancer tissue compared with adjacent tissues. Additionally, forest maps and the nomogram model indicated that elevated CBX2 expression was an independent prognostic factor in CRC. Moreover, we confirmed that the deletion of CBX2 markedly suppressed the proliferation and migration of CRC cells and . Furthermore, downregulation of CBX2 promotes CRC cell apoptosis and hinders the cell cycle. Mechanistically, our data demonstrated that deletion of CBX2 inhibited the MAPK signaling pathway by regulating the protein levels of Mettl3. In conclusion, our study demonstrated that CBX2 is a vital tumor suppressor in CRC and could be a promising anti-cancer therapeutic target.

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