Alpha 2.0
Login Register
» Articles » PMID: 26096166

Signaling Pathway of MAPK/ERK in Cell Proliferation, Differentiation, Migration, Senescence and Apoptosis

Overview
Journal J Recept Signal Transduct Res
Publisher Informa Healthcare
Specialties Biochemistry
Cell Biology
Physiology
Date 2015 Jun 23
PMID 26096166
Citations 760
Authors
Yu Sun
Wen-Zhou Liu
Tao Liu
Xu Feng
Nuo Yang
Hua-Fu Zhou
Affiliations
Soon will be listed here.
Abstract

The generic mitogen-activated protein kinases (MAPK) signaling pathway is shared by four distinct cascades, including the extracellular signal-related kinases (ERK1/2), Jun amino-terminal kinases (JNK1/2/3), p38-MAPK and ERK5. Mitogen-activated protein kinases/extracellular signal-regulated kinase (MAPK/ERK) pathway is reported to be associated with the cell proliferation, differentiation, migration, senescence and apoptosis. The literatures were searched extensively and this review was performed to review the role of MAPK/ERK signaling pathway in cell proliferation, differentiation, migration, senescence and apoptosis.

Citing Articles

Proteomic and phosphoproteomic signatures of aging mouse liver.

Mohallem R, Schaser A, Aryal U Geroscience. 2025; .

PMID: 40087212 DOI: 10.1007/s11357-025-01601-0.

Treatment-Related Mechanisms of Tibetan Medicine (TC) Aqueous Extract Against Mouse Gastroenteritis Caused by Yak-Origin Determined Using Intestinal Microbiome Analysis and Metabolomics.

Li D, Zhang K, Xue X, Bai Z, Yang L, Qi J Animals (Basel). 2025; 15(5).

PMID: 40076040 PMC: 11899446. DOI: 10.3390/ani15050755.

Synergistic effects of 6-shogaol and hyperthermia on ACHN renal cancer cells: modulation of ROS and heat shock pro-teins in cancer therapy.

Ahn C, Baek S Front Pharmacol. 2025; 16:1522285.

PMID: 40051570 PMC: 11882530. DOI: 10.3389/fphar.2025.1522285.

ZNF32 histidine 179 and 183 single-site and double-site mutations promote nuclear speckle formation but differentially regulate the proliferation of breast cancer cells.

Zhong C, Chen D, Wang F, Wang J, Li R, Li Y Front Cell Dev Biol. 2025; 13:1490231.

PMID: 40046230 PMC: 11880268. DOI: 10.3389/fcell.2025.1490231.

Standardized Leaf Extract Exhibited Antiproliferative Activity Against TGF-β-induced Prostate Stromal Cells (WPMY-1) Through G 1 Phase Cell Cycle Arrest SMAD2/3 and ERK1/2 Signaling Pathways.

Kanphet Y, Uttarawichien T, Vongsak B, Boonsom T, Nalinratana N, Sivaji S In Vivo. 2025; 39(2):778-794.

PMID: 40011003 PMC: 11884491. DOI: 10.21873/invivo.13882.