The Name Is Barrel, β-Barrel

Overview

Journal Methods Mol Biol

Specialty Molecular Biology

Date 2024 Mar 13

PMID 38478268

Authors

Scout Hayashi

Susan K Buchanan

Istvan Botos

Affiliations

Soon will be listed here.

Abstract

β-barrels are a class of membrane proteins made up of a cylindrical, anti-parallel β-sheet with a hydrophobic exterior and a hydrophilic interior. The majority of proteins found in the outer membranes (OMs) of Gram-negative bacteria, mitochondria, and chloroplasts are β-barrel outer membrane proteins (OMPs). β-barrel OMPs have a diverse repertoire of functions, including nutrient transport, secretion, bacterial virulence, and enzymatic activity. Here, we discuss the broad functional classes of β-barrel OMPs, how they are folded into the membrane, and the future of β-barrel OMP research and its applications.

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