Novel Spore-forming Species Exhibiting Intrinsic Resistance to Third- and Fourth-generation Cephalosporins and Description of Gen. Nov., Sp. Nov

Overview

Journal mBio

Publisher American Society for Microbiology

Specialty Microbiology

Date 2024 Mar 13

PMID 38477597

Authors

Georgios Miliotis

Pratyay Sengupta

Asif Hameed

Maria Chuvochina

Francesca McDonagh

Anna C Simpson

Ceth W Parker

Nitin K Singh

Punchappady D Rekha

Dearbhaile Morris

Karthik Raman

Nikos C Kyrpides

Philip Hugenholtz

Kasthuri Venkateswaran

Affiliations

Soon will be listed here.

Abstract

Importance: The significance of this research extends to understanding microbial survival and adaptation in oligotrophic environments, such as those found in SAF. Whole-genome sequencing of several strains isolated from Mars 2020 mission assembly cleanroom facilities, including the discovery of the novel species , highlights the resilience and antimicrobial resistance (AMR) in clinically relevant antibiotic classes of microbes in nutrient-scarce settings. The study also redefines the taxonomic classifications within the family, aligning genetic identities with phylogenetic data. Investigating ARG and virulence factors (VF) across these strains illuminates the microbial capability for resistance under resource-limited conditions while emphasizing the role of human-associated VF in microbial survival, informing sterilization practices and microbial management in similar oligotrophic settings beyond spacecraft assembly cleanrooms such as pharmaceutical and medical industry cleanrooms.

Citing Articles

sp. nov. isolated from a Mars 2020 spacecraft assembly facility and genomic potential for lasso peptide production in .

Hameed A, McDonagh F, Sengupta P, Miliotis G, Sivabalan S, Szydlowski L Microbiol Spectr. 2024; 13(1):e0137624.

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Validation List no. 219. Valid publication of new names and new combinations effectively published outside the IJSEM.

Oren A, Goker M Int J Syst Evol Microbiol. 2024; 74(9).

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