» Articles » PMID: 38475889

Suffix Sorting Via Matching Statistics

Overview
Publisher Biomed Central
Date 2024 Mar 13
PMID 38475889
Authors
Affiliations
Soon will be listed here.
Abstract

We introduce a new algorithm for constructing the generalized suffix array of a collection of highly similar strings. As a first step, we construct a compressed representation of the matching statistics of the collection with respect to a reference string. We then use this data structure to distribute suffixes into a partial order, and subsequently to speed up suffix comparisons to complete the generalized suffix array. Our experimental evidence with a prototype implementation (a tool we call sacamats) shows that on string collections with highly similar strings we can construct the suffix array in time competitive with or faster than the fastest available methods. Along the way, we describe a heuristic for fast computation of the matching statistics of two strings, which may be of independent interest.

Citing Articles

Marker discovery in the large.

Vieira Mourato B, Tsers I, Denker S, Klotzl F, Haubold B Bioinform Adv. 2024; 4(1):vbae113.

PMID: 39132289 PMC: 11310107. DOI: 10.1093/bioadv/vbae113.

References
1.
. Computational pan-genomics: status, promises and challenges. Brief Bioinform. 2016; 19(1):118-135. PMC: 5862344. DOI: 10.1093/bib/bbw089. View

2.
Garrison E, Siren J, Novak A, Hickey G, Eizenga J, Dawson E . Variation graph toolkit improves read mapping by representing genetic variation in the reference. Nat Biotechnol. 2018; 36(9):875-879. PMC: 6126949. DOI: 10.1038/nbt.4227. View

3.
Valenzuela D, Norri T, Valimaki N, Pitkanen E, Makinen V . Towards pan-genome read alignment to improve variation calling. BMC Genomics. 2018; 19(Suppl 2):87. PMC: 5954285. DOI: 10.1186/s12864-018-4465-8. View

4.
Kuhnle A, Mun T, Boucher C, Gagie T, Langmead B, Manzini G . Efficient Construction of a Complete Index for Pan-Genomics Read Alignment. J Comput Biol. 2020; 27(4):500-513. PMC: 7185338. DOI: 10.1089/cmb.2019.0309. View

5.
Auton A, Brooks L, Durbin R, Garrison E, Kang H, Korbel J . A global reference for human genetic variation. Nature. 2015; 526(7571):68-74. PMC: 4750478. DOI: 10.1038/nature15393. View