Polyphenols Influence the Development of Endometrial Cancer by Modulating the Gut Microbiota

Overview

Journal Nutrients

Date 2024 Mar 13

PMID 38474808

Authors

Ewa Baranowska-Wojcik

Anna Winiarska-Mieczan

Piotr Olcha

Malgorzata Kwiecien

Karolina Jachimowicz-Rogowska

Lukasz Nowakowski

Andrzej Miturski

Krzysztof Galczynski

Affiliations

Soon will be listed here.

Abstract

Dysbiosis of the microbiota in the gastrointestinal tract can induce the development of gynaecological tumours, particularly in postmenopausal women, by causing DNA damage and alterations in metabolite metabolism. Dysbiosis also complicates cancer treatment by influencing the body's immune response and disrupting the sensitivity to chemotherapy drugs. Therefore, it is crucial to maintain homeostasis in the gut microbiota through the effective use of food components that affect its structure. Recent studies have shown that polyphenols, which are likely to be the most important secondary metabolites produced by plants, exhibit prebiotic properties. They affect the structure of the gut microbiota and the synthesis of metabolites. In this review, we summarise the current state of knowledge, focusing on the impact of polyphenols on the development of gynaecological tumours, particularly endometrial cancer, and emphasising that polyphenol consumption leads to beneficial modifications in the structure of the gut microbiota.

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