The Cardioprotective Role of Nitrate-Rich Vegetables

Overview

Journal Foods

Specialty Biotechnology

Date 2024 Mar 13

PMID 38472804

Authors

Beata Olas

Affiliations

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Abstract

Nitric oxide (NO) is an inorganic radical produced by both the non-enzymatic nitrate (NO)-nitrite (NO)-NO pathway and enzymatic reactions catalyzed by nitric oxide synthase (NOS). Also, as nitrate and nitrite from dietary and other endogenous sources can be reduced back to nitric oxide in vivo, the endogenous NO level can be increased through the consumption of nitrate-rich vegetables. Ingestion of dietary NO has beneficial effects which have been attributed to a subsequent increase in NO: a signaling molecule that may regulate various systems, including the cardiovascular system. A diet rich in NO from green leafy and root vegetables has cardioprotective effects, with beetroot products being particularly good sources of NO. For example, various studies have demonstrated a significant increase in nitrite levels (regarded as markers of NO) in plasma after the intake of beetroot juice. The present review describes the current literature concerning the role of nitrate-rich vegetables (especially beetroot products) in the prophylaxis and treatment of cardiovascular diseases (CVDs). This review is based on studies identified in electronic databases, including PubMed, ScienceDirect, Web of Knowledge, Sci Finder, Web of Science, and SCOPUS.

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References

Joris P, Mensink R . Beetroot juice improves in overweight and slightly obese men postprandial endothelial function after consumption of a mixed meal. Atherosclerosis. 2013; 231(1):78-83. DOI: 10.1016/j.atherosclerosis.2013.09.001. View

Seals D, Jablonski K, Donato A . Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011; 120(9):357-75. PMC: 3482987. DOI: 10.1042/CS20100476. View

Govoni M, Jansson E, Weitzberg E, Lundberg J . The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide. 2008; 19(4):333-7. DOI: 10.1016/j.niox.2008.08.003. View

Cocksedge S, Causer A, Winyard P, Jones A, Bailey S . Oral Temperature and pH Influence Dietary Nitrate Metabolism in Healthy Adults. Nutrients. 2023; 15(3). PMC: 9919366. DOI: 10.3390/nu15030784. View

Clifford T, Howatson G, West D, Stevenson E . The potential benefits of red beetroot supplementation in health and disease. Nutrients. 2015; 7(4):2801-22. PMC: 4425174. DOI: 10.3390/nu7042801. View

Dudhe R, Dudhe A, Raut S . Significance of Inorganic Nitrate Supplement in Cardiovascular Health. Cardiovasc Hematol Agents Med Chem. 2021; 20(2):83-89. DOI: 10.2174/1871525719666210427130511. View

Kenjale A, Ham K, Stabler T, Robbins J, Johnson J, VanBruggen M . Dietary nitrate supplementation enhances exercise performance in peripheral arterial disease. J Appl Physiol (1985). 2011; 110(6):1582-91. PMC: 3119136. DOI: 10.1152/japplphysiol.00071.2011. View

Kapil V, Khambata R, Robertson A, Caulfield M, Ahluwalia A . Dietary nitrate provides sustained blood pressure lowering in hypertensive patients: a randomized, phase 2, double-blind, placebo-controlled study. Hypertension. 2014; 65(2):320-7. PMC: 4288952. DOI: 10.1161/HYPERTENSIONAHA.114.04675. View

Lee J, Stebbins C, Jung E, Nho H, Kim J, Chang M . Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 2015; 309(5):R459-66. DOI: 10.1152/ajpregu.00099.2015. View

10.

Hord N . Dietary nitrates, nitrites, and cardiovascular disease. Curr Atheroscler Rep. 2011; 13(6):484-92. DOI: 10.1007/s11883-011-0209-9. View

11.

Gonzalez A, Townsend J, Pinzone A, Hoffman J . Supplementation with Nitric Oxide Precursors for Strength Performance: A Review of the Current Literature. Nutrients. 2023; 15(3). PMC: 9921013. DOI: 10.3390/nu15030660. View

12.

Capper T, Siervo M, Clifford T, Taylor G, Iqbal W, West D . Pharmacokinetic Profile of Incremental Oral Doses of Dietary Nitrate in Young and Older Adults: A Crossover Randomized Clinical Trial. J Nutr. 2021; 152(1):130-139. PMC: 8754575. DOI: 10.1093/jn/nxab354. View

13.

Milton-Laskibar I, Martinez J, Portillo M . Current Knowledge on Beetroot Bioactive Compounds: Role of Nitrate and Betalains in Health and Disease. Foods. 2021; 10(6). PMC: 8229785. DOI: 10.3390/foods10061314. View

14.

Rolnik A, Olas B . The Plants of the Family as Agents in the Protection of Human Health. Int J Mol Sci. 2021; 22(6). PMC: 7999649. DOI: 10.3390/ijms22063009. View

15.

Notay K, Incognito A, Millar P . Acute beetroot juice supplementation on sympathetic nerve activity: a randomized, double-blind, placebo-controlled proof-of-concept study. Am J Physiol Heart Circ Physiol. 2017; 313(1):H59-H65. DOI: 10.1152/ajpheart.00163.2017. View

16.

van Velzen A, Sips A, Schothorst R, Lambers A, Meulenbelt J . The oral bioavailability of nitrate from nitrate-rich vegetables in humans. Toxicol Lett. 2008; 181(3):177-81. DOI: 10.1016/j.toxlet.2008.07.019. View

17.

Rolnik A, Soluch A, Kowalska I, Olas B . Antioxidant and hemostatic properties of preparations from Asteraceae family and their chemical composition - Comparative studies. Biomed Pharmacother. 2021; 142:111982. DOI: 10.1016/j.biopha.2021.111982. View

18.

Berry M, Justus N, Hauser J, Case A, Helms C, Basu S . Dietary nitrate supplementation improves exercise performance and decreases blood pressure in COPD patients. Nitric Oxide. 2014; 48:22-30. PMC: 4411191. DOI: 10.1016/j.niox.2014.10.007. View

19.

Vanhatalo A, Bailey S, Blackwell J, DiMenna F, Pavey T, Wilkerson D . Acute and chronic effects of dietary nitrate supplementation on blood pressure and the physiological responses to moderate-intensity and incremental exercise. Am J Physiol Regul Integr Comp Physiol. 2010; 299(4):R1121-31. DOI: 10.1152/ajpregu.00206.2010. View

20.

Fleenor B, Sindler A, Eng J, Nair D, Dodson R, Seals D . Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp Gerontol. 2012; 47(8):588-94. PMC: 3389216. DOI: 10.1016/j.exger.2012.05.004. View