Metabolic Syndrome is Not Associated with Erosive Hand Osteoarthritis: a Cross-sectional Study Using Data from the PROCOAC Cohort

Overview

Journal Sci Rep

Specialty Science

Date 2024 Mar 13

PMID 38472231

Authors

Maite Silva-Diaz

Sonia Pertega-Diaz

Vanesa Balboa-Barreiro

Carlos M Tilve-Alvarez

Ana Raga-Sivira

Ignacio Rego-Perez

Francisco J Blanco

Natividad Oreiro

Affiliations

Soon will be listed here.

Abstract

To delineate the phenotype of erosive hand osteoarthritis (EHOA) in a Spanish population and assess its correlation with metabolic syndrome. We conducted a cross-sectional study using baseline data from the Prospective Cohort of Osteoarthritis from A Coruña (PROCOAC). Demographic and clinical variables, obtained through questionnaires, clinical examinations, and patient analytics, were compared among individuals with hand OA, with and without EHOA. We performed appropriate univariate and multivariate stepwise regression analyses using SPSS v28. Among 1039 subjects diagnosed with hand OA, 303 exhibited EHOA. Multivariate logistic regression analysis revealed associations with inflamed joints, nodular hand OA, and total AUSCAN. Furthermore, the association with a lower prevalence of knee OA remained significant. The influence of metabolic syndrome (MetS) on EHOA patients was analyzed by including MetS as a covariate in the model. It was observed that MetS does not significantly impact the presence of EHOA, maintaining the effect size of other factors. In conclusion, in the PROCOAC cohort, EHOA is associated with nodular hand OA, inflammatory hand OA, and a higher total AUSCAN. However, EHOA is linked to a lower prevalence of knee OA. Importantly, in our cohort, no relationship was found between EHOA and MetS.

References

Marshall M, Peat G, Nicholls E, van der Windt D, Myers H, Dziedzic K . Subsets of symptomatic hand osteoarthritis in community-dwelling older adults in the United Kingdom: prevalence, inter-relationships, risk factor profiles and clinical characteristics at baseline and 3-years. Osteoarthritis Cartilage. 2013; 21(11):1674-84. PMC: 3819994. DOI: 10.1016/j.joca.2013.08.004. View

Tenti S, Ferretti F, Gusinu R, Gallo I, Giannotti S, Pozza A . Impact of thumb osteoarthritis on pain, function, and quality of life: a comparative study between erosive and non-erosive hand osteoarthritis. Clin Rheumatol. 2020; 39(7):2195-2206. DOI: 10.1007/s10067-020-04982-z. View

Allen K, Jordan J, Renner J, Kraus V . Validity, factor structure, and clinical relevance of the AUSCAN Osteoarthritis Hand Index. Arthritis Rheum. 2006; 54(2):551-6. DOI: 10.1002/art.21615. View

Marshall M, Watt F, Vincent T, Dziedzic K . Hand osteoarthritis: clinical phenotypes, molecular mechanisms and disease management. Nat Rev Rheumatol. 2018; 14(11):641-656. DOI: 10.1038/s41584-018-0095-4. View

Pereira D, Peleteiro B, Araujo J, Branco J, Santos R, Ramos E . The effect of osteoarthritis definition on prevalence and incidence estimates: a systematic review. Osteoarthritis Cartilage. 2011; 19(11):1270-85. DOI: 10.1016/j.joca.2011.08.009. View

Blanco F, Silva-Diaz M, Quevedo Vila V, Seoane-Mato D, Perez Ruiz F, Juan-Mas A . Prevalence of symptomatic osteoarthritis in Spain: EPISER2016 study. Reumatol Clin (Engl Ed). 2021; 17(8):461-470. DOI: 10.1016/j.reumae.2020.01.005. View

Williams B, Mancia G, Spiering W, Agabiti Rosei E, Azizi M, Burnier M . 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of.... J Hypertens. 2018; 36(10):1953-2041. DOI: 10.1097/HJH.0000000000001940. View

Haugen I, Mathiessen A, Slatkowsky-Christensen B, Magnusson K, Boyesen P, Sesseng S . Synovitis and radiographic progression in non-erosive and erosive hand osteoarthritis: is erosive hand osteoarthritis a separate inflammatory phenotype?. Osteoarthritis Cartilage. 2015; 24(4):647-54. DOI: 10.1016/j.joca.2015.11.014. View

Cicuttini F, Baker J, Hart D, Spector T . Relation between Heberden's nodes and distal interphalangeal joint osteophytes and their role as markers of generalised disease. Ann Rheum Dis. 1998; 57(4):246-8. PMC: 1752580. DOI: 10.1136/ard.57.4.246. View

10.

van Delft M, van Beest S, Kloppenburg M, Trouw L, Ioan-Facsinay A . Presence of Autoantibodies in Erosive Hand Osteoarthritis and Association with Clinical Presentation. J Rheumatol. 2018; 46(1):101-105. DOI: 10.3899/jrheum.180256. View

11.

Felson D, Zhang Y, Hannan M, Naimark A, Weissman B, Aliabadi P . Risk factors for incident radiographic knee osteoarthritis in the elderly: the Framingham Study. Arthritis Rheum. 1997; 40(4):728-33. DOI: 10.1002/art.1780400420. View

12.

Naranjo Hernandez A, Diaz Del Campo Fontecha P, Aguado Acin M, Arboleya Rodriguez L, Casado Burgos E, Castaneda S . Recommendations by the Spanish Society of Rheumatology on Osteoporosis. Reumatol Clin (Engl Ed). 2018; 15(4):188-210. DOI: 10.1016/j.reuma.2018.09.004. View

13.

Dahaghin S, Bierma-Zeinstra S, Ginai A, Pols H, Hazes J, Koes B . Prevalence and pattern of radiographic hand osteoarthritis and association with pain and disability (the Rotterdam study). Ann Rheum Dis. 2004; 64(5):682-7. PMC: 1755481. DOI: 10.1136/ard.2004.023564. View

14.

Arreguin Reyes R, Lopez Lopez C, Alvarez Hernandez E, Ramirez G, Montes Castillo M, Vazquez-Mellado J . Evaluation of hand function in rheumatic disease. Validation and usefulness of the Spanish version AUSCAN, m-SACRAH and Cochin questionnaires. Reumatol Clin. 2012; 8(5):250-4. DOI: 10.1016/j.reuma.2012.03.005. View

15.

Bijsterbosch J, Watt I, Meulenbelt I, Rosendaal F, Huizinga T, Kloppenburg M . Clinical burden of erosive hand osteoarthritis and its relationship to nodes. Ann Rheum Dis. 2010; 69(10):1784-8. DOI: 10.1136/ard.2009.125435. View

16.

Sanchez-Santos M, Judge A, Gulati M, Spector T, Hart D, Newton J . Association of metabolic syndrome with knee and hand osteoarthritis: A community-based study of women. Semin Arthritis Rheum. 2018; 48(5):791-798. DOI: 10.1016/j.semarthrit.2018.07.007. View

17.

Haugen I, Englund M, Aliabadi P, Niu J, Clancy M, Kvien T . Prevalence, incidence and progression of hand osteoarthritis in the general population: the Framingham Osteoarthritis Study. Ann Rheum Dis. 2011; 70(9):1581-6. PMC: 3867970. DOI: 10.1136/ard.2011.150078. View

18.

CRAIN D . Interphalangeal osteoarthritis. JAMA. 1961; 175:1049-53. DOI: 10.1001/jama.1961.03040120011003. View

19.

Ramonda R, Frallonardo P, Musacchio E, Vio S, Punzi L . Joint and bone assessment in hand osteoarthritis. Clin Rheumatol. 2013; 33(1):11-9. DOI: 10.1007/s10067-013-2404-2. View

20.

Kwok W, Vlieland T, Rosendaal F, Huizinga T, Kloppenburg M . Limitations in daily activities are the major determinant of reduced health-related quality of life in patients with hand osteoarthritis. Ann Rheum Dis. 2010; 70(2):334-6. DOI: 10.1136/ard.2010.133603. View