Perirenal Adipose Tissue Contains a Subpopulation of Cold-inducible Adipocytes Derived from Brown-to-white Conversion

Overview

Journal Elife

Specialty Biology

Date 2024 Mar 12

PMID 38470102

Authors

Houyu Zhang

Yan Li

Carlos F Ibanez

Meng Xie

Affiliations

Soon will be listed here.

Abstract

Perirenal adipose tissue (PRAT) is a unique visceral depot that contains a mixture of brown and white adipocytes. The origin and plasticity of such cellular heterogeneity remains unknown. Here, we combine single-nucleus RNA sequencing with genetic lineage tracing to reveal the existence of a distinct subpopulation of & adipocytes that arises from brown-to-white conversion during postnatal life in the periureter region of mouse PRAT. Cold exposure restores expression and a thermogenic phenotype in this subpopulation. These cells have a transcriptome that is distinct from subcutaneous beige adipocytes and may represent a unique type of cold-recruitable adipocytes. These results pave the way for studies of PRAT physiology and mechanisms controlling the plasticity of brown/white adipocyte phenotypes.

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