Made to Order: Emergency Myelopoiesis and Demand-adapted Innate Immune Cell Production

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2024 Mar 12

PMID 38467802

Authors

James W Swann

Oakley C Olson

Emmanuelle Passegue

Affiliations

Soon will be listed here.

Abstract

Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly regulated to maintain a stable output of blood cells in health, the haematopoietic system is capable of extensive remodelling in response to external challenges, prioritizing the production of certain cell types at the expense of others. In this Review, we consider how acute insults, such as infections and cytotoxic drug-induced myeloablation, cause molecular, cellular and metabolic changes in haematopoietic stem and progenitor cells at multiple levels of the haematopoietic hierarchy to drive accelerated production of the mature myeloid cells needed to resolve the initiating insult. Moreover, we discuss how dysregulation or subversion of these emergency myelopoiesis mechanisms contributes to the progression of chronic inflammatory diseases and cancer.

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