Simulated Microgravity Increases CD226 Lin CD117 Sca1 Mesenchymal Stem Cells in Mice

Overview

Journal Physiol Rep

Specialty Physiology

Date 2024 Mar 11

PMID 38467556

Authors

Wenjing Zhou

Yi Li

Yongli Hou

Wenli Dan

Lihua Chen

Fei Shi

Fang Zhao

Liang Fang

Affiliations

Soon will be listed here.

Abstract

Microgravity is one of the most common causes counting for the bone loss. Mesenchymal stem cells (MSCs) contribute greatly to the differentiation and function of bone related cells. The development of novel MSCs biomarkers is critical for implementing effective therapies for microgravity induced bone loss. We aimed to find the new molecules involved in the differentiation and function of MSCs in mouse simulated microgravity model. We found CD226 was preferentially expressed on a subset of MSCs. Simulation of microgravity treatment significantly increased the proportion of CD226 Lin CD117 Sca1 MSCs. The CD226 MSCs produced higher IL-6, M-CSF, RANKL and lower CD200 expression, and promoted osteoclast differentiation. This study provides pivotal information to understand the role of CD226 in MSCs, and inspires new ideas for prevention of bone loss related diseases.

Citing Articles

Simulated microgravity increases CD226 Lin CD117 Sca1 mesenchymal stem cells in mice.

Zhou W, Li Y, Hou Y, Dan W, Chen L, Shi F Physiol Rep. 2024; 12(5):e15971.

PMID: 38467556 PMC: 10927603. DOI: 10.14814/phy2.15971.

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