Relationship of Serum Prestin Levels to the Severity of Sensorineural Hearing Loss

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Mar 11

PMID 38465090

Authors

Ali Rasheed H Al Samarrai

Bakr M Mahdi

Kourosh Parham

Affiliations

Soon will be listed here.

Abstract

Objective: Prestin is an outer hair cell (OHC) protein responsible for increasing cochlear sensitivity and has been proposed as a biomarker. We aimed to evaluate whether the serum prestin level is related to the severity of chronic sensorineural hearing loss (SNHL).

Methods: Ninety subjects were recruited from the patient base at Samarra public hospitals and clinics in Iraq from January to October of 2022. They were divided into three groups equally: a group of healthy people without hearing loss (G0), a group with moderate SNHL (G1), and a group with severe SNHL (G2). The subjects ranged from 20 to 80 years of age and included 51 males and 39 females. Blood samples were collected, then serum was separated, and enzyme-linked immunosorbent assays were performed to quantify the levels of prestin.

Results: Hearing thresholds were sequentially statistically higher across the three groups. While prestin levels were significantly higher in G1 and G2 than that in G0, there were no differences between the G1 and G2 levels. Serum prestin levels were positively correlated with hearing thresholds in G1, but not G2.

Conclusion: Our results suggest that in the clinical setting, prestin is sensitive to chronic mild to moderate SNHL (i.e., up to 40-60 dB), not more severe loss. This range is consistent with the added sensitivity provided by OHCs in the cochlea and provides support for prestin as a biomarker of OHC-mediated SNHL.

Citing Articles

Changes in Plasma Levels of Prestin and Otolin-1 in Dental Students.

Lee J, Miser S, OConnor K, Bedinghaus C, Tomeo G, Badawy M Cureus. 2025; 16(12):e75719.

PMID: 39811239 PMC: 11730730. DOI: 10.7759/cureus.75719.

Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss.

Gadenstaetter A, Krumpoeck P, Auinger A, Yildiz E, Tu A, Matula C Otolaryngol Head Neck Surg. 2024; 171(6):1825-1833.

PMID: 38988299 PMC: 11605028. DOI: 10.1002/ohn.895.

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