Prestin Amplifies Cardiac Motor Functions

Overview

Journal Cell Rep

Publisher Cell Press

Specialties Biology
Cell Biology
Molecular Biology

Date 2021 May 5

PMID 33951436

Citations 9

Authors

Xiao-Dong Zhang

Phung N Thai

Lu Ren

Maria Cristina Perez Flores

Hannah A Ledford

Seojin Park

Jeong Han Lee

Choong-Ryoul Sihn

Che-Wei Chang

Wei Chun Chen

Valeriy Timofeyev

Jian Zuo

James W Chan

Ebenezer N Yamoah

Nipavan Chiamvimonvat

Affiliations

Soon will be listed here.

Abstract

Cardiac cells generate and amplify force in the context of cardiac load, yet the membranous sheath enclosing the muscle fibers-the sarcolemma-does not experience displacement. That the sarcolemma sustains beat-to-beat pressure changes without experiencing significant distortion is a muscle-contraction paradox. Here, we report that an elastic element-the motor protein prestin (Slc26a5)-serves to amplify actin-myosin force generation in mouse and human cardiac myocytes, accounting partly for the nonlinear capacitance of cardiomyocytes. The functional significance of prestin is underpinned by significant alterations of cardiac contractility in Prestin-knockout mice. Prestin was previously considered exclusive to the inner ear's outer hair cells; however, our results show that prestin serves a broader cellular motor function.

Citing Articles

MYH1 deficiency disrupts outer hair cell electromotility, resulting in hearing loss.

Jung J, Joo S, Min H, Roh J, Kim K, Ma J Exp Mol Med. 2024; 56(11):2423-2435.

PMID: 39482536 PMC: 11612406. DOI: 10.1038/s12276-024-01338-4.

Verification of Outer Hair Cell Motor Protein, Prestin, as a Serological Biomarker for Mouse Cochlear Damage.

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Prestin in Human Perilymph, Cerebrospinal Fluid, and Blood as a Biomarker for Hearing Loss.

Gadenstaetter A, Krumpoeck P, Auinger A, Yildiz E, Tu A, Matula C Otolaryngol Head Neck Surg. 2024; 171(6):1825-1833.

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Relationship of Serum Prestin Levels to the Severity of Sensorineural Hearing Loss.

Al Samarrai A, Mahdi B, Parham K Cureus. 2024; 16(2):e53763.

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Evaluation of inner ear damage by mastoid drilling with measurement of serum prestin (SLC26A5) levels.

Baskadem Yilmazer A, Tanrisever O, Alagoz M, Yilmazer R, Goker A, Tutar B Braz J Otorhinolaryngol. 2024; 90(2):101380.

PMID: 38237483 PMC: 10828577. DOI: 10.1016/j.bjorl.2023.101380.

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