The Inflammatory Spectrum of Cardiomyopathies

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Mar 11

PMID 38464847

Authors

Nicolas Musigk

Phillip Suwalski

Ainoosh Golpour

DeLisa Fairweather

Karin Klingel

Pilar Martin

Andrea Frustaci

Leslie T Cooper

Thomas F Luscher

Ulf Landmesser

Bettina Heidecker

Affiliations

Soon will be listed here.

Abstract

Infiltration of the myocardium with various cell types, cytokines and chemokines plays a crucial role in the pathogenesis of cardiomyopathies including inflammatory cardiomyopathies and myocarditis. A more comprehensive understanding of the precise immune mechanisms involved in acute and chronic myocarditis is essential to develop novel therapeutic approaches. This review offers a comprehensive overview of the current knowledge of the immune landscape in cardiomyopathies based on etiology. It identifies gaps in our knowledge about cardiac inflammation and emphasizes the need for new translational approaches to improve our understanding thus enabling development of novel early detection methods and more effective treatments.

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