Identification of Hub Genes Associated with Infection and Type 2 Diabetes Mellitus: A Pilot Bioinformatics Study

Overview

Journal World J Diabetes

Publisher Baishideng Publishing Group

Specialty Endocrinology

Date 2024 Mar 11

PMID 38464370

Authors

Han Chen

Guo-Xin Zhang

Xiao-Ying Zhou

Affiliations

Soon will be listed here.

Abstract

Background: () infection is related to various extragastric diseases including type 2 diabetes mellitus (T2DM). However, the possible mechanisms connecting infection and T2DM remain unknown.

Aim: To explore potential molecular connections between infection and T2DM.

Methods: We extracted gene expression arrays from three online datasets (GSE60427, GSE27411 and GSE115601). Differentially expressed genes (DEGs) commonly present in patients with infection and T2DM were identified. Hub genes were validated using human gastric biopsy samples. Correlations between hub genes and immune cell infiltration, miRNAs, and transcription factors (TFs) were further analyzed.

Results: A total of 67 DEGs were commonly presented in patients with infection and T2DM. Five significantly upregulated hub genes, including , , , , and , were finally identified, all of which are closely related to immune cell infiltration. The gene-miRNA analysis detected 13 miRNAs with at least two gene cross-links. TF-gene interaction networks showed that was coregulated by 26 TFs, the largest number of TFs among the 5 hub genes.

Conclusion: We identified five hub genes that may have molecular connections between infection and T2DM. This study provides new insights into the pathogenesis of -induced onset of T2DM.

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