-Mediated Oxidative Stress and Gastric Diseases: A Review

Overview

Journal Front Microbiol

Specialty Microbiology

Date 2022 Feb 25

PMID 35211104

Authors

Lu Han

Xu Shu

Jian Wang

Affiliations

Soon will be listed here.

Abstract

Gastric cancer is considered to be a type of gastrointestinal tumor and is mostly accompanied by (HP) infection at the early stage. Hence, the long-term colonization of the gastric mucosa by HP as a causative factor for gastrointestinal diseases cannot be ignored. The virulence factors secreted by the bacterium activate the signaling pathway of oxidative stress and mediate chronic inflammatory response in the host cells. The virulence factors also thwart the antibacterial effect of neutrophils. Subsequently, DNA methylation is induced, which causes continuous cell proliferation and evolution toward low-grade-differentiated gastric cells. This process provides the pathological basis for the occurrence of progressive gastric cancer. Therefore, this review aims to summarize the oxidative stress response triggered by HP in the gastric mucosa and the subsequent signaling pathways. The findings are expected to help in the formulation of new targeted drugs for preventing the occurrence of early gastric cancer and its progression to middle and advanced cancer.

Citing Articles

Bioaccessible Bread Melanoidins Modulate Oxidative Stress, Reduce Inflammation and Suppress Adhesion of to Caco-2 Cells.

Gerardi G, Temino V, Salazar-Mardones G, Diaz-Morales N, Melero B, Bocigas C Nutrients. 2025; 17(4).

PMID: 40004976 PMC: 11858341. DOI: 10.3390/nu17040648.

Oxidative Stress and Reprogramming of Lipid Metabolism in Cancers.

Li S, Yuan H, Li L, Li Q, Lin P, Li K Antioxidants (Basel). 2025; 14(2).

PMID: 40002387 PMC: 11851681. DOI: 10.3390/antiox14020201.

Advancements in the Pathogenesis, Diagnosis, and Therapeutic Implications of Intestinal Bacteria.

Lu D, Ma X, Tao K, Lei H Curr Issues Mol Biol. 2025; 47(2).

PMID: 39996827 PMC: 11853859. DOI: 10.3390/cimb47020106.

Enhancement of host defense against infection through modulation of the gastrointestinal microenvironment by Lp05.

Dong Y, Han M, Qi Y, Wu Y, Zhou Z, Jiang D Front Immunol. 2025; 15:1469885.

PMID: 39896799 PMC: 11782045. DOI: 10.3389/fimmu.2024.1469885.

Helicobacter pylori and gastric cancer: mechanisms and new perspectives.

Duan Y, Xu Y, Dou Y, Xu D J Hematol Oncol. 2025; 18(1):10.

PMID: 39849657 PMC: 11756206. DOI: 10.1186/s13045-024-01654-2.

References

Yamaoka Y . Mechanisms of disease: Helicobacter pylori virulence factors. Nat Rev Gastroenterol Hepatol. 2010; 7(11):629-41. PMC: 3137895. DOI: 10.1038/nrgastro.2010.154. View

Zhang X, Arnold I, Muller A . Mechanisms of persistence, innate immune activation and immunomodulation by the gastric pathogen Helicobacter pylori. Curr Opin Microbiol. 2020; 54:1-10. DOI: 10.1016/j.mib.2020.01.003. View

Georgakilas A, Martin O, Bonner W . p21: A Two-Faced Genome Guardian. Trends Mol Med. 2017; 23(4):310-319. DOI: 10.1016/j.molmed.2017.02.001. View

Nicolussi A, DInzeo S, Capalbo C, Giannini G, Coppa A . The role of peroxiredoxins in cancer. Mol Clin Oncol. 2017; 6(2):139-153. PMC: 5351761. DOI: 10.3892/mco.2017.1129. View

Shirin H, Pinto J, Liu L, Merzianu M, Sordillo E, Moss S . Helicobacter pylori decreases gastric mucosal glutathione. Cancer Lett. 2001; 164(2):127-33. DOI: 10.1016/s0304-3835(01)00383-4. View

Wei J, Noto J, Zaika E, Romero-Gallo J, Piazuelo M, Schneider B . Bacterial CagA protein induces degradation of p53 protein in a p14ARF-dependent manner. Gut. 2014; 64(7):1040-8. PMC: 4312278. DOI: 10.1136/gutjnl-2014-307295. View

Sterbenc A, Jarc E, Poljak M, Homan M . virulence genes. World J Gastroenterol. 2019; 25(33):4870-4884. PMC: 6737321. DOI: 10.3748/wjg.v25.i33.4870. View

Backert S, Clyne M . Pathogenesis of Helicobacter pylori infection. Helicobacter. 2011; 16 Suppl 1:19-25. DOI: 10.1111/j.1523-5378.2011.00876.x. View

Lee D, Jung D, Yu S, Lee Y, Choi B, Lee Y . Regulation of SIRT3 signal related metabolic reprogramming in gastric cancer by oncoprotein CagA. Oncotarget. 2017; 8(45):78365-78378. PMC: 5667968. DOI: 10.18632/oncotarget.18695. View

10.

Furukawa-Hibi Y, Yoshida-Araki K, Ohta T, Ikeda K, Motoyama N . FOXO forkhead transcription factors induce G(2)-M checkpoint in response to oxidative stress. J Biol Chem. 2002; 277(30):26729-32. DOI: 10.1074/jbc.C200256200. View

11.

Espinoza J, Matsumoto A, Tanaka H, Matsumura I . Gastric microbiota: An emerging player in Helicobacter pylori-induced gastric malignancies. Cancer Lett. 2017; 414:147-152. DOI: 10.1016/j.canlet.2017.11.009. View

12.

Luo J, Bai L, Tao J, Wen Y, Li M, Zhu Y . Autophagy induced by H. pylori VacA regulated the survival mechanism of the SGC7901 human gastric cancer cell line. Genes Genomics. 2021; 43(10):1223-1230. PMC: 8429402. DOI: 10.1007/s13258-021-01151-7. View

13.

Benitez J, Marra R, Reyes J, Calvete O . A genetic origin for acid-base imbalance triggers the mitochondrial damage that explains the autoimmune response and drives to gastric neuroendocrine tumours. Gastric Cancer. 2019; 23(1):52-63. DOI: 10.1007/s10120-019-00982-4. View

14.

Cai H, Ye F, Michel A, Murphy G, Sasazuki S, Taylor P . Helicobacter pylori blood biomarker for gastric cancer risk in East Asia. Int J Epidemiol. 2016; 45(3):774-81. PMC: 5841796. DOI: 10.1093/ije/dyw078. View

15.

Ansari S, Yamaoka Y . Role of vacuolating cytotoxin A in infection and its impact on gastric pathogenesis. Expert Rev Anti Infect Ther. 2020; 18(10):987-996. DOI: 10.1080/14787210.2020.1782739. View

16.

Chen S, Zhang R, Duan G . Pathogenic mechanisms of the oncoprotein CagA in H. pylori-induced gastric cancer (Review). Oncol Rep. 2016; 36(6):3087-3094. DOI: 10.3892/or.2016.5145. View

17.

Doulberis M, Kountouras J, Rogler G . Reconsidering the "protective" hypothesis of Helicobacter pylori infection in eosinophilic esophagitis. Ann N Y Acad Sci. 2020; 1481(1):59-71. DOI: 10.1111/nyas.14449. View

18.

Moonens K, Hamway Y, Neddermann M, Reschke M, Tegtmeyer N, Kruse T . adhesin HopQ disrupts dimerization in human CEACAMs. EMBO J. 2018; 37(13). PMC: 6028033. DOI: 10.15252/embj.201798665. View

19.

Molina-Castro S, Tiffon C, Giraud J, Boeuf H, Sifre E, Giese A . The Hippo Kinase LATS2 Controls Helicobacter pylori-Induced Epithelial-Mesenchymal Transition and Intestinal Metaplasia in Gastric Mucosa. Cell Mol Gastroenterol Hepatol. 2019; 9(2):257-276. PMC: 6957828. DOI: 10.1016/j.jcmgh.2019.10.007. View

20.

Davarpanah E, Jafarzadeh A, Nemati M, Bassagh A, Abasi M, Khosravimashizi A . Circulating concentration of interleukin-37 in Helicobacter pylori-infected patients with peptic ulcer: Its association with IL-37 related gene polymorphisms and bacterial virulence factor CagA. Cytokine. 2019; 126:154928. DOI: 10.1016/j.cyto.2019.154928. View