Inverse Associations of Cord Blood Mitochondrial DNA Copy Number with Childhood Adiposity

Overview

Journal Obesity (Silver Spring)

Specialties Endocrinology
Nutritional Sciences
Physiology

Date 2024 Mar 8

PMID 38454311

Authors

Aalekhya Reddam

Tessa R Bloomquist

Lindsey T Covell

Heng Hu

Sharon E Oberfield

Dympna Gallagher

Rachel L Miller

Jeff Goldsmith

Andrew G Rundle

Andrea A Baccarelli

Julie B Herbstman

Allison Kupsco

Affiliations

Soon will be listed here.

Abstract

Objective: The objective of this study was to examine associations between umbilical cord mitochondrial DNA copy number (mtDNAcn) and adiposity across childhood.

Methods: In a prospective birth cohort of Dominican and African American children from New York City, New York (1998-2006), mtDNAcn was measured in cord blood. Children (N = 336) were evaluated for their height, weight, and bioimpedance at age 5, 7, 9, and 11 years. We used linear mixed-effects models to assess associations of mtDNAcn tertiles in cord blood with child BMI, BMI z scores, fat mass index, and body fat percentage. Latent class growth models and interactions between mtDNAcn and child age or child age were used to assess associations between age and adiposity trajectories.

Results: BMI was, on average, 1.5 kg/m higher (95% CI: 0.58, 2.5) in individuals with mtDNAcn in the low- compared with the middle-mtDNAcn tertile. Results were similar for BMI z score, fat mass index, and body fat percentage. Moreover, children in the low-mtDNAcn group had increased odds of being in an "increasing" or "high-stable" adiposity class.

Conclusions: Lower mtDNAcn at birth may predict greater childhood adiposity, highlighting the potential key role of perinatal mitochondrial function in adiposity during development.

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