Human Trophoblast Stem Cells Restrict Human Cytomegalovirus Replication

Overview

Journal J Virol

Publisher American Society for Microbiology

Date 2024 Mar 7

PMID 38451085

Authors

Tyler B Rollman

Zachary W Berkebile

Hiroaki Okae

Vivian J Bardwell

Micah D Gearhart

Craig J Bierle

Affiliations

Soon will be listed here.

Abstract

Importance: Placental infection plays a central role in human cytomegalovirus (HCMV) pathogenesis during pregnancy, but the species specificity of HCMV and the limited availability and lifespan of primary trophoblasts have been persistent barriers to understanding how infection impacts this vital organ. Human trophoblast stem cells (TSCs) represent a new approach to modeling viral infection early in placental development. This study reveals that TSCs, like other stem cell types, restrict HCMV replication. However, infection perturbs the expression of genes involved in differentiation and cell fate determination, pointing to a mechanism by which HCMV could cause placental injury.

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