Nomograms to Predict Long-term Survival for Patients with Gallbladder Carcinoma After Resection

Overview

Journal Cancer Rep (Hoboken)

Specialty Oncology

Date 2024 Mar 5

PMID 38441306

Authors

Shilei Bai

Pinghua Yang

JiLiang Qiu

Jie Wang

Liu Liu

Chunyan Wang

Huifeng Wang

Zhijian Wen

Baohua Zhang

Affiliations

Soon will be listed here.

Abstract

Background: Surgical resection remains the primary treatment option for gallbladder carcinoma (GBC). However, there is a pressing demand for prognostic tools that can refine patients' treatment choices and tailor personalized therapies accordingly.

Aims: The nomograms were constructed using the data of a training cohort (n = 378) of GBC patients at Eastern Hepatobiliary Surgery Hospital (EHBH) between 2008 and 2018. The model's performance was validated in GBC patients (n = 108) at Guangzhou Centre from 2007 to 2018.

Methods And Results: The 5-year overall survival (OS) rate in the training cohort was 24.4%. Multivariate analyses were performed using preoperative and postoperative data to identify independent predictors of OS. These predictors were then incorporated into preoperative and postoperative nomograms, respectively. The C-index of the preoperative nomogram was 0.661 (95% CI, 0.627 to 0.694) for OS prediction and correctly delineated four subgroups (5-year OS rates: 48.1%, 19.0%, 15.6%, and 8.1%, p < 0.001). The C-index of the postoperative nomogram was 0.778 (95%CI, 0.756 -0.800). Furthermore, this nomogram was superior to the 8th TNM system in both C-index and the net benefit on decision curve analysis. The results were externally validated.

Conclusion: The two nomograms showed an optimally prognostic prediction in GBC patients after curative-intent resection.

Citing Articles

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Nomograms to predict long-term survival for patients with gallbladder carcinoma after resection.

Bai S, Yang P, Qiu J, Wang J, Liu L, Wang C Cancer Rep (Hoboken). 2024; 7(3):e1991.

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References

Sakata J, Shirai Y, Wakai T, Ajioka Y, Hatakeyama K . Number of positive lymph nodes independently determines the prognosis after resection in patients with gallbladder carcinoma. Ann Surg Oncol. 2010; 17(7):1831-40. DOI: 10.1245/s10434-009-0899-1. View

Aloia T, Jarufe N, Javle M, Maithel S, Roa J, Adsay V . Gallbladder cancer: expert consensus statement. HPB (Oxford). 2015; 17(8):681-90. PMC: 4527853. DOI: 10.1111/hpb.12444. View

Wen Z, Si A, Yang J, Yang P, Yang X, Liu H . Elevation of CA19-9 and CEA is associated with a poor prognosis in patients with resectable gallbladder carcinoma. HPB (Oxford). 2017; 19(11):951-956. DOI: 10.1016/j.hpb.2017.06.011. View

Vickers A, Elkin E . Decision curve analysis: a novel method for evaluating prediction models. Med Decis Making. 2006; 26(6):565-74. PMC: 2577036. DOI: 10.1177/0272989X06295361. View

Are C . Common controversies in the management of gallbladder cancer. J Natl Compr Canc Netw. 2014; 12(5 Suppl):833-5. DOI: 10.6004/jnccn.2014.0201. View

Wen C, Tang J, Wang T, Luo H . A nomogram for predicting cancer-specific survival for elderly patients with gallbladder cancer. BMC Gastroenterol. 2022; 22(1):444. PMC: 9632126. DOI: 10.1186/s12876-022-02544-y. View

Koerkamp B, Wiggers J, Gonen M, Doussot A, Allen P, Besselink M . Survival after resection of perihilar cholangiocarcinoma-development and external validation of a prognostic nomogram. Ann Oncol. 2015; 26(9):1930-1935. PMC: 4754626. DOI: 10.1093/annonc/mdv279. View

Bai S, Yang P, Qiu J, Wang J, Liu L, Wang C . Nomograms to predict long-term survival for patients with gallbladder carcinoma after resection. Cancer Rep (Hoboken). 2024; 7(3):e1991. PMC: 10913079. DOI: 10.1002/cnr2.1991. View

Wang S, Fuller C, Kim J, Sittig D, Thomas Jr C, Ravdin P . Prediction model for estimating the survival benefit of adjuvant radiotherapy for gallbladder cancer. J Clin Oncol. 2008; 26(13):2112-7. DOI: 10.1200/JCO.2007.14.7934. View

10.

Amini N, Kim Y, Wilson A, Margonis G, Ethun C, Poultsides G . Prognostic Implications of Lymph Node Status for Patients With Gallbladder Cancer: A Multi-Institutional Study. Ann Surg Oncol. 2016; 23(9):3016-23. PMC: 5450040. DOI: 10.1245/s10434-016-5243-y. View

11.

Murakami Y, Uemura K, Sudo T, Hashimoto Y, Nakashima A, Kondo N . Prognostic factors of patients with advanced gallbladder carcinoma following aggressive surgical resection. J Gastrointest Surg. 2011; 15(6):1007-16. DOI: 10.1007/s11605-011-1479-9. View

12.

Balachandran V, Gonen M, Smith J, DeMatteo R . Nomograms in oncology: more than meets the eye. Lancet Oncol. 2015; 16(4):e173-80. PMC: 4465353. DOI: 10.1016/S1470-2045(14)71116-7. View

13.

Hong E, Kim K, Lee J, Lee W, Chung M, Kim Y . Surgical outcome and prognostic factors in patients with gallbladder carcinoma. Korean J Hepatobiliary Pancreat Surg. 2015; 18(4):129-37. PMC: 4492352. DOI: 10.14701/kjhbps.2014.18.4.129. View

14.

Bai Y, Liu Z, Xiong J, Xu W, Lin J, Long J . Nomogram to predict overall survival after gallbladder cancer resection in China. World J Gastroenterol. 2018; 24(45):5167-5178. PMC: 6288645. DOI: 10.3748/wjg.v24.i45.5167. View

15.

Fong Y, Jarnagin W, Blumgart L . Gallbladder cancer: comparison of patients presenting initially for definitive operation with those presenting after prior noncurative intervention. Ann Surg. 2000; 232(4):557-69. PMC: 1421188. DOI: 10.1097/00000658-200010000-00011. View

16.

Igami T, Ebata T, Yokoyama Y, Sugawara G, Mizuno T, Yamaguchi J . Combined extrahepatic bile duct resection for locally advanced gallbladder carcinoma: does it work?. World J Surg. 2015; 39(7):1810-7. DOI: 10.1007/s00268-015-3011-y. View

17.

Cleary S, Tan J, Law C, Coburn N . Treatment considerations for gallbladder cancer should include extent of surgery. J Clin Oncol. 2008; 26(27):4521-2. DOI: 10.1200/JCO.2008.18.5066. View

18.

Yang P, Qiu J, Li J, Wu D, Wan X, Lau W . Nomograms for Pre- and Postoperative Prediction of Long-term Survival for Patients Who Underwent Hepatectomy for Multiple Hepatocellular Carcinomas. Ann Surg. 2015; 263(4):778-86. DOI: 10.1097/SLA.0000000000001339. View

19.

Shirai Y, Sakata J, Wakai T, Ohashi T, Ajioka Y, Hatakeyama K . Assessment of lymph node status in gallbladder cancer: location, number, or ratio of positive nodes. World J Surg Oncol. 2012; 10:87. PMC: 3532237. DOI: 10.1186/1477-7819-10-87. View

20.

Lim H, Seo D, Park D, Lee S, Lee S, Kim M . Prognostic factors in patients with gallbladder cancer after surgical resection: analysis of 279 operated patients. J Clin Gastroenterol. 2012; 47(5):443-8. DOI: 10.1097/MCG.0b013e3182703409. View