From Neglect to Spotlight: the Underappreciated Role of B Cells in Cutaneous Inflammatory Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Mar 1

PMID 38426103

Authors

Eun-Gang Lee

Ji Eun Oh

Affiliations

Soon will be listed here.

Abstract

The skin, covering our entire body as its largest organ, manifests enormous complexities and a profound interplay of systemic and local responses. In this heterogeneous domain, B cells were considered strangers. Yet, recent studies have highlighted their existence in the skin and their distinct role in modulating cutaneous immunity across various immune contexts. Accumulating evidence is progressively shedding light on the significance of B cells in maintaining skin health and in skin disorders. Herein, we integrate current insights on the systemic and local contributions of B cells in three prevalent inflammatory skin conditions: Pemphigus Vulgaris (PV), Systemic Lupus Erythematosus (SLE), and Atopic Dermatitis (AD), underscoring the previously underappreciated importance of B cells within skin immunity. Moreover, we address the potential adverse effects of current treatments used for skin diseases, emphasizing their unintentional consequences on B cells. These comprehensive approaches may pave the way for innovative therapeutic strategies that effectively address the intricate nature of skin disorders.

Citing Articles

IgG from Dermatophagoides pteronyssinus (Der p)-atopic individuals modulates non-atopic thymic B cell phenotype (alfa-4/beta-7) and cytokine production (IFN-γ, IL-9, and IL-10) with direct membrane interaction.

de-Apoena Reche D, Machado N, Fagundes B, Bergamasco I, de Sousa T, do Nascimento L Sci Rep. 2024; 14(1):7274.

PMID: 38538762 PMC: 10973508. DOI: 10.1038/s41598-024-57950-x.

References

Fetter T, Niebel D, Braegelmann C, Wenzel J . Skin-Associated B Cells in the Pathogenesis of Cutaneous Autoimmune Diseases-Implications for Therapeutic Approaches. Cells. 2020; 9(12). PMC: 7762338. DOI: 10.3390/cells9122627. View

Pignarre A, Chatonnet F, Caron G, Haas M, Desmots F, Fest T . Plasmablasts derive from CD23- activated B cells after the extinction of IL-4/STAT6 signaling and IRF4 induction. Blood. 2020; 137(9):1166-1180. DOI: 10.1182/blood.2020005083. View

Kunkel E, Butcher E . Plasma-cell homing. Nat Rev Immunol. 2003; 3(10):822-9. DOI: 10.1038/nri1203. View

Oh J, Iijima N, Song E, Lu P, Klein J, Jiang R . Migrant memory B cells secrete luminal antibody in the vagina. Nature. 2019; 571(7763):122-126. PMC: 6609483. DOI: 10.1038/s41586-019-1285-1. View

Massone C, Kodama K, Salmhofer W, Abe R, Shimizu H, Parodi A . Lupus erythematosus panniculitis (lupus profundus): clinical, histopathological, and molecular analysis of nine cases. J Cutan Pathol. 2005; 32(6):396-404. DOI: 10.1111/j.0303-6987.2005.00351.x. View

Yoshihara Y, Ishiuji Y, Yoshizaki A, Kurita M, Hayashi M, Ishiji T . IL-10-Producing Regulatory B Cells Are Decreased in Patients with Atopic Dermatitis. J Invest Dermatol. 2018; 139(2):475-478. DOI: 10.1016/j.jid.2018.08.016. View

Lee A, Sandhu S, Imlay-Gillespie L, Mulligan S, Shumack S . Successful use of Bruton's kinase inhibitor, ibrutinib, to control paraneoplastic pemphigus in a patient with paraneoplastic autoimmune multiorgan syndrome and chronic lymphocytic leukaemia. Australas J Dermatol. 2017; 58(4):e240-e242. DOI: 10.1111/ajd.12615. View

Rott L, Briskin M, Butcher E . Expression of alpha4beta7 and E-selectin ligand by circulating memory B cells: implications for targeted trafficking to mucosal and systemic sites. J Leukoc Biol. 2000; 68(6):807-14. View

Lyons R, Narain S, Nichols C, Satoh M, Reeves W . Effective use of autoantibody tests in the diagnosis of systemic autoimmune disease. Ann N Y Acad Sci. 2005; 1050:217-28. DOI: 10.1196/annals.1313.023. View

10.

Yuan H, Zhou S, Liu Z, Cong W, Fei X, Zeng W . Pivotal Role of Lesional and Perilesional T/B Lymphocytes in Pemphigus Pathogenesis. J Invest Dermatol. 2017; 137(11):2362-2370. DOI: 10.1016/j.jid.2017.05.032. View

11.

Pasparakis M, Haase I, Nestle F . Mechanisms regulating skin immunity and inflammation. Nat Rev Immunol. 2014; 14(5):289-301. DOI: 10.1038/nri3646. View

12.

Matsushita T, Hamaguchi Y, Hasegawa M, Takehara K, Fujimoto M . Decreased levels of regulatory B cells in patients with systemic sclerosis: association with autoantibody production and disease activity. Rheumatology (Oxford). 2015; 55(2):263-7. DOI: 10.1093/rheumatology/kev331. View

13.

Zhang X, Li L, Jung J, Xiang S, Hollmann C, Choi Y . The distinct roles of T cell-derived cytokines and a novel follicular dendritic cell-signaling molecule 8D6 in germinal center-B cell differentiation. J Immunol. 2001; 167(1):49-56. DOI: 10.4049/jimmunol.167.1.49. View

14.

Allie S, Bradley J, Mudunuru U, Schultz M, Graf B, Lund F . The establishment of resident memory B cells in the lung requires local antigen encounter. Nat Immunol. 2018; 20(1):97-108. PMC: 6392030. DOI: 10.1038/s41590-018-0260-6. View

15.

Dey-Rao R, Sinha A . Analyses of Skin and Peripheral Blood Transcriptional Data in Cutaneous Lupus Reveals CCR2-A Novel Potential Therapeutic Target. Front Immunol. 2019; 10:640. PMC: 6450170. DOI: 10.3389/fimmu.2019.00640. View

16.

Tokura Y, Hayano S . Subtypes of atopic dermatitis: From phenotype to endotype. Allergol Int. 2021; 71(1):14-24. DOI: 10.1016/j.alit.2021.07.003. View

17.

Genestier L, Taillardet M, Mondiere P, Gheit H, Bella C, Defrance T . TLR agonists selectively promote terminal plasma cell differentiation of B cell subsets specialized in thymus-independent responses. J Immunol. 2007; 178(12):7779-86. DOI: 10.4049/jimmunol.178.12.7779. View

18.

Czarnowicki T, Gonzalez J, Bonifacio K, Shemer A, Xiangyu P, Kunjravia N . Diverse activation and differentiation of multiple B-cell subsets in patients with atopic dermatitis but not in patients with psoriasis. J Allergy Clin Immunol. 2015; 137(1):118-129.e5. DOI: 10.1016/j.jaci.2015.08.027. View

19.

Naik S, Bouladoux N, Wilhelm C, Molloy M, Salcedo R, Kastenmuller W . Compartmentalized control of skin immunity by resident commensals. Science. 2012; 337(6098):1115-9. PMC: 3513834. DOI: 10.1126/science.1225152. View

20.

Adachi Y, Onodera T, Yamada Y, Daio R, Tsuiji M, Inoue T . Distinct germinal center selection at local sites shapes memory B cell response to viral escape. J Exp Med. 2015; 212(10):1709-23. PMC: 4577849. DOI: 10.1084/jem.20142284. View