The Antioxidant Activity of Polysaccharides from

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2024 Feb 29

PMID 38419855

Authors

Peiwen Su

Honghao Qiu

Lishan Liang

Luo Weng

Yingjie Liu

Jiajun Liu

Liyan Wu

Fanxin Meng

Affiliations

Soon will be listed here.

Abstract

The purpose of this study was to investigate the antioxidant activity of polysaccharides. It explored whether polysaccharides (AgP) could prevent HepG cells from HO-induced oxidative damage. The results demonstrated that HepG cells were significantly protected by AgP, and efficiently suppressed the production of reactive oxygen species (ROS) in HepG cells. Additionally, AgP significantly decreased the abnormal leakage of alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) caused by HO, protecting cell membrane integrity. It was discovered that AgP was also found to regulate the activities of antioxidant enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-PX), while reducing malondialdehyde (MDA), thus protecting cells from oxidative damage. According to the flow cytometry analysis and measurement of caspase-3, caspase-8, and caspase-9 activities, AgP could modulate apoptosis-related proteins and attenuate ROS-mediated cell apoptosis.

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