Evaluation of Immuno-histochemical Markers in Oral Squamous Cell Carcinoma

Overview

Journal Bioinformation

Specialty Biology

Date 2024 Feb 28

PMID 38415034

Authors

Yadavalli Guruprasad

Priya Singhal

Neha Gupta

Bhavna Jha Kukreja

Bharti Gupta

Pankaj Kukreja

Ramanpal Singh Makkad

Dhaval Niranjan Mehta

Affiliations

Soon will be listed here.

Abstract

Evaluation of immuno-histochemical (IHC) markers like p53, p63, PDPN, C-erb-B2, CK19, and VEGF in oral squamous cell carcinoma (OSCCs) is of interest to dentists. Sixty formalin-fixed paraffin embedded tissue blocks from the Department of Oral Pathology, New Horizon Dental College and Research, Institute, Sakri, Bilaspur, Chhattisgarh, India. The conventional IHC method was used to assess the expression of p53, p63, PDPN, C- erb-B2, CK19 and VEGF using the different antibodies. Data shows that P53, p63 had high values of labeling index (LI) of staining while PDPN, C-erb-B2 had low values of LI of staining. The values of LI of staining for CK19, and VEGF were in between the two types of IHCs. Combining the analysis of multiple IHC markers for OSCC can yield precise cancer diagnosis results.

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