Diagnostic Utility of Cytokeratin 17 Expression in Oral Squamous Cell Carcinoma: A Review

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2022 Aug 22

PMID 35989819

Authors

Ankita Gyanchandani

Samarth Shukla

Sunita Vagha

Sourya Acharaya

Ravindra P Kadu

Affiliations

Soon will be listed here.

Abstract

One of the most common oral malignancies is oral squamous cell carcinoma (OSCC). Although the prevalence of oral cancer varies worldwide, it is generally agreed that the oral cavity is a common anatomical site for cancer, depending primarily on the country (and even particular region in some countries) and gender of the patients. Finding diagnostic markers for OSCC is critical for early diagnosis and personalised treatment of patients. Because they are overexpressed in OSCC relative to normal mucosa, cytokeratins (CKs), intermediate filaments of the cytoskeletons, are possibilities for diagnostic markers of OSCC. CK17 should be targeted as a diagnostic marker for OSCC among the CKs, as multiple other CKs have been linked to the disease. This study aims to assess the immuno-histochemistry expression of CK17 and to investigate whether there is a link between CK17 and OSCC differentiation.

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References

Sanguansin S, Kosanwat T, Juengsomjit R, Poomsawat S . Diagnostic Value of Cytokeratin 17 during Oral Carcinogenesis: An Immunohistochemical Study. Int J Dent. 2021; 2021:4089549. PMC: 8629611. DOI: 10.1155/2021/4089549. View

Duraiyan J, Govindarajan R, Kaliyappan K, Palanisamy M . Applications of immunohistochemistry. J Pharm Bioallied Sci. 2012; 4(Suppl 2):S307-9. PMC: 3467869. DOI: 10.4103/0975-7406.100281. View

Wei K, Zhang L, Yang X, Zhong L, Zhou X, Pan H . Overexpression of cytokeratin 17 protein in oral squamous cell carcinoma in vitro and in vivo. Oral Dis. 2008; 15(1):111-7. DOI: 10.1111/j.1601-0825.2008.01501.x. View

Agarwal A, Bhola N, Kambala R, Borle R . Touch Imprint Cytology: Can It Serve as an Alternative to Frozen Section in Intraoperative Assessment of Cervical Metastasis in Oral Squamous Cell Carcinoma?. J Oral Maxillofac Surg. 2019; 77(5):994-999. DOI: 10.1016/j.joms.2019.01.011. View

Gadbail A, Chaudhary M, Sarode S, Gondivkar S, Belekar L, Mankar-Gadbail M . Ki67, CD105 and α-smooth muscle actin expression in disease progression model of oral submucous fibrosis. J Investig Clin Dent. 2019; 10(4):e12443. DOI: 10.1111/jicd.12443. View

Nobusawa A, Sano T, Negishi A, Yokoo S, Oyama T . Immunohistochemical staining patterns of cytokeratins 13, 14, and 17 in oral epithelial dysplasia including orthokeratotic dysplasia. Pathol Int. 2014; 64(1):20-7. DOI: 10.1111/pin.12125. View

Kitamura R, Toyoshima T, Tanaka H, Kawano S, Kiyosue T, Matsubara R . Association of cytokeratin 17 expression with differentiation in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2012; 138(8):1299-310. PMC: 3397222. DOI: 10.1007/s00432-012-1202-6. View

Gadbail A, Chaudhary M, Sarode S, Gawande M, Korde S, Tekade S . Ki67, CD105, and α-SMA expressions better relate the binary oral epithelial dysplasia grading system of World Health Organization. J Oral Pathol Med. 2017; 46(10):921-927. DOI: 10.1111/jop.12612. View

Matsuhira A, Noguchi S, Sato K, Tanaka Y, Yamamoto G, Mishima K . Cytokeratin 13, Cytokeratin 17, Ki-67 and p53 Expression in Upper Layers of Epithelial Dysplasia Surrounding Tongue Squamous Cell Carcinoma. Bull Tokyo Dent Coll. 2015; 56(4):223-31. DOI: 10.2209/tdcpublication.56.223. View

10.

Mehrotra R, Yadav S . Oral squamous cell carcinoma: etiology, pathogenesis and prognostic value of genomic alterations. Indian J Cancer. 2006; 43(2):60-6. DOI: 10.4103/0019-509x.25886. View

11.

Markopoulos A . Current aspects on oral squamous cell carcinoma. Open Dent J. 2012; 6:126-30. PMC: 3428647. DOI: 10.2174/1874210601206010126. View

12.

Gadbail A, Korde S, Chaudhary M, Sarode S, Gondivkar S, Dande R . Ki67, CD105, and α-SMA Expression Supports Biological Distinctness of Oral Squamous Cell Carcinoma Arising in the Background of Oral Submucous Fibrosis. Asian Pac J Cancer Prev. 2020; 21(7):2067-2074. PMC: 7573415. DOI: 10.31557/APJCP.2020.21.7.2067. View

13.

Coelho B, Peterle G, Santos M, Agostini L, Maia L, Stur E . Keratins 17 and 19 expression as prognostic markers in oral squamous cell carcinoma. Genet Mol Res. 2015; 14(4):15123-32. DOI: 10.4238/2015.November.24.21. View

14.

Gadbail A, Chaudhary M, Sarode S, Gondivkar S, Tekade S, Zade P . Ki67, CD105, and α-SMA expression supports the transformation relevant dysplastic features in the atrophic epithelium of oral submucous fibrosis. PLoS One. 2018; 13(7):e0200171. PMC: 6042727. DOI: 10.1371/journal.pone.0200171. View

15.

Wei K, Zhang L, Yang X, Han W, Zhong L, Ye D . [Expression of cytokeratin 17 in oral squamous cell carcinoma]. Hua Xi Kou Qiang Yi Xue Za Zhi. 2011; 29(4):404-8. View