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Accelerated Elastin Degradation by Age-disease Interaction: a Common Feature in Age-related Diseases

Overview
Journal NPJ Aging
Publisher Springer Nature
Specialty Geriatrics
Date 2024 Feb 27
PMID 38413600
Authors
Affiliations
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Abstract

Aging is a major driving force for many diseases but the relationship between chronological age, the aging process and age-related diseases is not fully understood. Fragmentation and loss of ultra-long-lived elastin are key features in aging and several age-related diseases leading to increased mortality. By comparing the relationship between age and elastin turnover with healthy volunteers, we show that accelerated elastin turnover by age-disease interaction is a common feature of age-related diseases.

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References
1.
Heinz A . Elastic fibers during aging and disease. Ageing Res Rev. 2021; 66:101255. DOI: 10.1016/j.arr.2021.101255. View

2.
Toyama B, Hetzer M . Protein homeostasis: live long, won't prosper. Nat Rev Mol Cell Biol. 2012; 14(1):55-61. PMC: 3570024. DOI: 10.1038/nrm3496. View

3.
Huang J, Kuzmanova E, Dicker A, Keir H, Finch S, Aliberti S . Serum Desmosine Is Associated with Long-Term All-Cause and Cardiovascular Mortality in Bronchiectasis. Am J Respir Crit Care Med. 2020; 202(6):897-899. DOI: 10.1164/rccm.202002-0434LE. View

4.
. Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair. Circulation. 2017; 136(9):787-797. PMC: 5571881. DOI: 10.1161/CIRCULATIONAHA.117.028433. View

5.
Vidaillac C, Yong V, Jaggi T, Soh M, Chotirmall S . Gender differences in bronchiectasis: a real issue?. Breathe (Sheff). 2018; 14(2):108-121. PMC: 5980467. DOI: 10.1183/20734735.000218. View