Exploring the Microbial Landscape of Neonatal Skin Flora: A Comprehensive Review

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2024 Feb 26

PMID 38406113

Authors

Aditya Jain

Revat J Meshram

Sham Lohiya

Ankita Patel

Divyanshi Kaplish

Affiliations

Soon will be listed here.

Abstract

This comprehensive review explores the intricate landscape of the neonatal skin microbiome, shedding light on its dynamic composition, developmental nuances, and influential factors. The neonatal period represents a critical window during which microbial colonization significantly impacts local skin health and the foundational development of the immune system. Factors such as mode of delivery and gestational age underscore the vulnerability of neonates to disruptions in microbial establishment. Key findings emphasize the broader systemic implications of the neonatal skin microbiome, extending beyond immediate health outcomes to influence susceptibility to infections, allergies, and immune-related disorders. This review advocates for a paradigm shift in neonatal care, proposing strategies to preserve and promote a healthy skin microbiome for long-term health benefits. The implications of this research extend to public health, where interventions targeting the neonatal skin microbiome could potentially mitigate diseases originating in early life. As we navigate the intersection of research and practical applications, bridging the gap between knowledge and implementation becomes imperative for translating these findings into evidence-based practices and improving neonatal well-being on a broader scale.

References

Gupta A, Nair S . Dynamics of Insect-Microbiome Interaction Influence Host and Microbial Symbiont. Front Microbiol. 2020; 11:1357. PMC: 7333248. DOI: 10.3389/fmicb.2020.01357. View

Boxberger M, Cenizo V, Cassir N, La Scola B . Challenges in exploring and manipulating the human skin microbiome. Microbiome. 2021; 9(1):125. PMC: 8166136. DOI: 10.1186/s40168-021-01062-5. View

Marissen J, Gomez de Aguero M, Chandorkar P, Reichert L, Glaser K, Speer C . The Delicate Skin of Preterm Infants: Barrier Function, Immune-Microbiome Interaction, and Clinical Implications. Neonatology. 2023; 120(3):295-307. DOI: 10.1159/000529026. View

Dhariwala M, Scharschmidt T . Baby's skin bacteria: first impressions are long-lasting. Trends Immunol. 2021; 42(12):1088-1099. PMC: 9206859. DOI: 10.1016/j.it.2021.10.005. View

Murdaca G, Greco M, Negrini S, Casciaro M, Gangemi S . The Role of Skin and Gut Microbiome and Epigenetic Modifications in Skin-Autoimmune Disorders. Curr Mol Med. 2020; 21(4):283-290. DOI: 10.2174/1566524020666200812222324. View

Rathje K, Mortzfeld B, Hoeppner M, Taubenheim J, Bosch T, Klimovich A . Dynamic interactions within the host-associated microbiota cause tumor formation in the basal metazoan Hydra. PLoS Pathog. 2020; 16(3):e1008375. PMC: 7081986. DOI: 10.1371/journal.ppat.1008375. View

Lee H, Kim M . Skin Barrier Function and the Microbiome. Int J Mol Sci. 2022; 23(21). PMC: 9654002. DOI: 10.3390/ijms232113071. View

Byrd A, Belkaid Y, Segre J . The human skin microbiome. Nat Rev Microbiol. 2018; 16(3):143-155. DOI: 10.1038/nrmicro.2017.157. View

Akacin I, Ersoy S, Doluca O, Gungormusler M . Comparing the significance of the utilization of next generation and third generation sequencing technologies in microbial metagenomics. Microbiol Res. 2022; 264:127154. DOI: 10.1016/j.micres.2022.127154. View

10.

Choi H, Chang J . Targeted Therapy for Cancers: From Ongoing Clinical Trials to FDA-Approved Drugs. Int J Mol Sci. 2023; 24(17). PMC: 10487969. DOI: 10.3390/ijms241713618. View

11.

Serghiou I, Webber M, Hall L . An update on the current understanding of the infant skin microbiome and research challenges. Curr Opin Microbiol. 2023; 75:102364. DOI: 10.1016/j.mib.2023.102364. View

12.

Teittinen A, Virta L, Li M, Wang J . Factors influencing the biodiversity of three microbial groups within and among islands of the Baltic Sea. FEMS Microbiol Ecol. 2021; 97(5). PMC: 8044292. DOI: 10.1093/femsec/fiab049. View

13.

Pereira M, Redanz S, Kriegel M . Skin Deep: The Role of the Microbiota in Cutaneous Autoimmunity. J Invest Dermatol. 2022; 142(3 Pt B):834-840. DOI: 10.1016/j.jid.2021.12.005. View

14.

Derilus D, Godoy-Vitorino F, Rosado H, Agosto E, Dominguez-Bello M, Cavallin H . An in-depth survey of the microbial landscape of the walls of a neonatal operating room. PLoS One. 2020; 15(4):e0230957. PMC: 7122808. DOI: 10.1371/journal.pone.0230957. View

15.

Smith C, Prasad V . Targeted Cancer Therapies. Am Fam Physician. 2021; 103(3):155-163. View

16.

Pascal M, Perez-Gordo M, Caballero T, Escribese M, Lopez Longo M, Luengo O . Microbiome and Allergic Diseases. Front Immunol. 2018; 9:1584. PMC: 6056614. DOI: 10.3389/fimmu.2018.01584. View

17.

Smythe P, Wilkinson H . The Skin Microbiome: Current Landscape and Future Opportunities. Int J Mol Sci. 2023; 24(4). PMC: 9963692. DOI: 10.3390/ijms24043950. View

18.

Canchy L, Kerob D, Demessant A, Amici J . Wound healing and microbiome, an unexpected relationship. J Eur Acad Dermatol Venereol. 2023; 37 Suppl 3:7-15. DOI: 10.1111/jdv.18854. View

19.

Jansma J, El Aidy S . Understanding the host-microbe interactions using metabolic modeling. Microbiome. 2021; 9(1):16. PMC: 7819158. DOI: 10.1186/s40168-020-00955-1. View

20.

Dominguez-Bello M, Costello E, Contreras M, Magris M, Hidalgo G, Fierer N . Delivery mode shapes the acquisition and structure of the initial microbiota across multiple body habitats in newborns. Proc Natl Acad Sci U S A. 2010; 107(26):11971-5. PMC: 2900693. DOI: 10.1073/pnas.1002601107. View