The Role of Selenitetriglycerides in Enhancing Antioxidant Defense Mechanisms in Peripartum Holstein-Friesian Cows

Overview

Journal Animals (Basel)

Date 2024 Feb 24

PMID 38396578

Authors

Katarzyna Zarczynska

Pawel Brym

Dawid Tobolski

Affiliations

Soon will be listed here.

Abstract

The transition period in high-yielding dairy cows is a critical phase marked by an elevated risk of oxidative stress. This study evaluated the effect of oral selenitetriglyceride supplementation on oxidative stress management in periparturient cows. A controlled experiment was conducted on 12 cows, divided into two groups: the experimental group (STG) received selenitetriglycerides (0.5 mg Se/kg BW), while the control group (CON) was given a placebo, starting 12 days before calving until the calving day. Blood and liver tissue samples were collected at predetermined intervals around the time of parturition. The study observed a significant increase in serum selenium levels and NEFA stabilization in the STG group compared with the control. Antioxidant parameters indicated elevated GSH-Px and CAT concentrations in the STG group. Liver gene expression analysis revealed a significant increase in SOD2 mRNA levels in the STG group (FC = 4.68, < 0.01). Conversely, GSH-Px3 expression significantly decreased (FC = 0.10, < 0.05) on the 7th day postpartum in the CON group. However, SOD1, SOD3, and CAT expressions remained stable in both groups. These findings highlight the beneficial role of selenitetriglycerides in enhancing antioxidant capacity and influencing specific gene expressions associated with oxidative stress management in dairy cows during the peripartum period.

References

Schonfeld P, Wojtczak L . Fatty acids as modulators of the cellular production of reactive oxygen species. Free Radic Biol Med. 2008; 45(3):231-41. DOI: 10.1016/j.freeradbiomed.2008.04.029. View

Sordillo L, Raphael W . Significance of metabolic stress, lipid mobilization, and inflammation on transition cow disorders. Vet Clin North Am Food Anim Pract. 2013; 29(2):267-78. DOI: 10.1016/j.cvfa.2013.03.002. View

Phillippo M, Arthur J, Price J, Halliday G . The effects of selenium, housing and management on the incidence of pneumonia in housed calves. Vet Rec. 1987; 121(22):509-12. DOI: 10.1136/vr.121.22.509. View

Arthur J . The glutathione peroxidases. Cell Mol Life Sci. 2001; 57(13-14):1825-35. PMC: 11147127. DOI: 10.1007/pl00000664. View

Bertoni G, Trevisi E, Han X, Bionaz M . Effects of inflammatory conditions on liver activity in puerperium period and consequences for performance in dairy cows. J Dairy Sci. 2008; 91(9):3300-10. DOI: 10.3168/jds.2008-0995. View

Zhao L, Zong W, Zhang H, Liu R . Kidney Toxicity and Response of Selenium Containing Protein-glutathione Peroxidase (Gpx3) to CdTe QDs on Different Levels. Toxicol Sci. 2018; 168(1):201-208. DOI: 10.1093/toxsci/kfy297. View

Sordillo L, Aitken S . Impact of oxidative stress on the health and immune function of dairy cattle. Vet Immunol Immunopathol. 2008; 128(1-3):104-9. DOI: 10.1016/j.vetimm.2008.10.305. View

Abuelo A, Hernandez J, Benedito J, Castillo C . The importance of the oxidative status of dairy cattle in the periparturient period: revisiting antioxidant supplementation. J Anim Physiol Anim Nutr (Berl). 2014; 99(6):1003-16. DOI: 10.1111/jpn.12273. View

Jastrzebski Z, Czyzewska-Szafran H, Remiszewska M, Fijalek Z, Fitak B, Suchocki P . Pharmacokinetics of selol, a new agent containing selenium, in rats. Drugs Exp Clin Res. 1997; 23(1):7-11. View

10.

Koller L, Exon J . The two faces of selenium-deficiency and toxicity--are similar in animals and man. Can J Vet Res. 1986; 50(3):297-306. PMC: 1255217. View

11.

Pilarczyk B, Jankowiak D, Tomza-Marciniak A, Pilarczyk R, Sablik P, Drozd R . Selenium concentration and glutathione peroxidase (GSH-Px) activity in serum of cows at different stages of lactation. Biol Trace Elem Res. 2011; 147(1-3):91-6. DOI: 10.1007/s12011-011-9271-y. View

12.

Wroblewski M, Wroblewska J, Nuszkiewicz J, Pawlowska M, Wesolowski R, Wozniak A . The Role of Selected Trace Elements in Oxidoreductive Homeostasis in Patients with Thyroid Diseases. Int J Mol Sci. 2023; 24(5). PMC: 10003705. DOI: 10.3390/ijms24054840. View

13.

Hall J, Bobe G, Vorachek W, Estill C, Mosher W, Pirelli G . Effect of supranutritional maternal and colostral selenium supplementation on passive absorption of immunoglobulin G in selenium-replete dairy calves. J Dairy Sci. 2014; 97(7):4379-91. DOI: 10.3168/jds.2013-7481. View

14.

Belinskaia D, Voronina P, Shmurak V, Vovk M, Batalova A, Jenkins R . The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin. Antioxidants (Basel). 2020; 9(10). PMC: 7601824. DOI: 10.3390/antiox9100966. View

15.

Dominiak A, Wilkaniec A, Jesko H, Czapski G, Lenkiewicz A, Kurek E . Selol, an organic selenium donor, prevents lipopolysaccharide-induced oxidative stress and inflammatory reaction in the rat brain. Neurochem Int. 2017; 108:66-77. DOI: 10.1016/j.neuint.2017.02.014. View

16.

Ponnampalam E, Kiani A, Santhiravel S, Holman B, Lauridsen C, Dunshea F . The Importance of Dietary Antioxidants on Oxidative Stress, Meat and Milk Production, and Their Preservative Aspects in Farm Animals: Antioxidant Action, Animal Health, and Product Quality-Invited Review. Animals (Basel). 2022; 12(23). PMC: 9738477. DOI: 10.3390/ani12233279. View

17.

Pregel P, Bollo E, Cannizzo F, Biolatti B, Contato E, Biolatti P . Antioxidant capacity as a reliable marker of stress in dairy calves transported by road. Vet Rec. 2005; 156(2):53-4. DOI: 10.1136/vr.156.2.53. View

18.

Mikula R, Pruszynska-Oszmalek E, Pszczola M, Rzasinska J, Sassek M, Nowak K . Changes in metabolic and hormonal profiles during transition period in dairy cattle - the role of spexin. BMC Vet Res. 2021; 17(1):359. PMC: 8605515. DOI: 10.1186/s12917-021-03069-4. View

19.

Sochacka M, Giebultowicz J, Remiszewska M, Suchocki P, Wroczynski P . Effects of Selol 5% supplementation on the activity or concentration of antioxidants and malondialdehyde level in the blood of healthy mice. Pharmacol Rep. 2014; 66(2):301-10. DOI: 10.1016/j.pharep.2013.10.004. View

20.

STOWE H, Herdt T . Clinical assessment of selenium status of livestock. J Anim Sci. 1992; 70(12):3928-33. DOI: 10.2527/1992.70123928x. View