The Universal Soldier: Enzymatic and Non-Enzymatic Antioxidant Functions of Serum Albumin

Overview

Journal Antioxidants (Basel)

Date 2020 Oct 14

PMID 33050223

Citations 33

Authors

Daria A Belinskaia

Polina A Voronina

Vladimir I Shmurak

Mikhail A Vovk

Anastasia A Batalova

Richard O Jenkins

Nikolay V Goncharov

Affiliations

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Abstract

As a carrier of many biologically active compounds, blood is exposed to oxidants to a greater extent than the intracellular environment. Serum albumin plays a key role in antioxidant defence under both normal and oxidative stress conditions. This review evaluates data published in the literature and from our own research on the mechanisms of the enzymatic and non-enzymatic activities of albumin that determine its participation in redox modulation of plasma and intercellular fluid. For the first time, the results of numerous clinical, biochemical, spectroscopic and computational experiments devoted to the study of allosteric modulation of the functional properties of the protein associated with its participation in antioxidant defence are analysed. It has been concluded that it is fundamentally possible to regulate the antioxidant properties of albumin with various ligands, and the binding and/or enzymatic features of the protein by changing its redox status. The perspectives for using the antioxidant properties of albumin in practice are discussed.

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