Risk Factors of Recurrence After Robot-assisted Laparoscopic Partial Nephrectomy for Solitary Localized Renal Cell Carcinoma

Overview

Journal Sci Rep

Specialty Science

Date 2024 Feb 23

PMID 38396061

Authors

Jae Hoon Chung

Wan Song

Minyong Kang

Hyun Hwan Sung

Hwang Gyun Jeon

Byong Chang Jeong

Seong Soo Jeon

Hyun Moo Lee

Seong Il Seo

Affiliations

Soon will be listed here.

Abstract

To evaluate the recurrence rate and risk factors of recurrence after robot-assisted laparoscopic partial nephrectomy for solitary renal cell carcinoma (RCC). A total of 1265 cases of initial solitary localized RCC were analyzed. The baseline characteristics, complexity (REANL nephrometry score), intra- and peri-operative outcomes, and recurrence were evaluated. Logistic regression was performed to evaluate the factors affecting recurrence after RAPN for solitary localized RCC. Recurrence after robot-assisted partial nephrectomy (RAPN) occurred in 29 patients (2.29%). The median follow-up was 36.0 months. The N domain (nearness to collecting system/sinus) (odd ratio (OR) 3.517, 95% confidence interval (CI) 1.557-7.945, p = 0.002), operation time (OR 1.005, 95% CI 1.001-1.010, p = 0.013), and perioperative transfusion (OR 5.450, 95% CI 1.197-24.816, p = 0.028) affected recurrence. Distant metastasis among patients with recurrence was significantly associated with nearness to the collecting system/sinus (OR 2.982, 95% CI 1.162-7.656, p = 0.023) and distance between the mass and collecting system/sinus (OR 0.758, 95% CI 0.594-0.967, p = 0.026). Nearness to the collecting system/sinus, operation time, and perioperative transfusion affect recurrence after RAPN for solitary localized RCC. Moreover, the proximity to the collecting system/sinus and distance between the mass and collecting system/sinus were significantly related to distant metastasis after RAPN.

Citing Articles

MiR-501-3p/SPC24 axis affects cell proliferation, migration, invasion, apoptosis, and prognosis in renal cell carcinoma.

Liang A, Huang J, He X, Tang X, Xu X, Chen M Braz J Med Biol Res. 2025; 58:e13507.

PMID: 39907402 PMC: 11793156. DOI: 10.1590/1414-431X2024e13507.

References

Ristau B, Handorf E, Cahn D, Kutikov A, Uzzo R, Smaldone M . Partial nephrectomy is not associated with an overall survival advantage over radical nephrectomy in elderly patients with stage Ib-II renal masses: An analysis of the national cancer data base. Cancer. 2018; 124(19):3839-3848. DOI: 10.1002/cncr.31582. View

Kunath F, Schmidt S, Krabbe L, Miernik A, Dahm P, Cleves A . Partial nephrectomy versus radical nephrectomy for clinical localised renal masses. Cochrane Database Syst Rev. 2017; 5:CD012045. PMC: 6481491. DOI: 10.1002/14651858.CD012045.pub2. View

Miller D, Hollingsworth J, Hafez K, Daignault S, Hollenbeck B . Partial nephrectomy for small renal masses: an emerging quality of care concern?. J Urol. 2006; 175(3 Pt 1):853-7. DOI: 10.1016/S0022-5347(05)00422-2. View

Joshi S, Uzzo R . Renal Tumor Anatomic Complexity: Clinical Implications for Urologists. Urol Clin North Am. 2017; 44(2):179-187. DOI: 10.1016/j.ucl.2016.12.004. View

Khalifeh A, Kaouk J, Bhayani S, Rogers C, Stifelman M, Tanagho Y . Positive surgical margins in robot-assisted partial nephrectomy: a multi-institutional analysis of oncologic outcomes (leave no tumor behind). J Urol. 2013; 190(5):1674-9. DOI: 10.1016/j.juro.2013.05.110. View

Cheng X, Zhang H, Hamad A, Huang H, Tsung A . Surgery-mediated tumor-promoting effects on the immune microenvironment. Semin Cancer Biol. 2022; 86(Pt 3):408-419. PMC: 11770836. DOI: 10.1016/j.semcancer.2022.01.006. View

Kume H, Suzuki M, Fujimura T, Fukuhara H, Enomoto Y, Nishimatsu H . Distant metastasis of renal cell carcinoma with a diameter of 3 cm or less-which is aggressive cancer?. J Urol. 2010; 184(1):64-8. DOI: 10.1016/j.juro.2010.03.019. View

Klett D, Tsivian M, Packiam V, Lohse C, Ahmed M, Potretzke T . Partial versus radical nephrectomy in clinical T2 renal masses. Int J Urol. 2021; 28(11):1149-1154. DOI: 10.1111/iju.14664. View

Huang R, Zhang C, Wang X, Hu H . Partial Nephrectomy Versus Radical Nephrectomy for Clinical T2 or Higher Stage Renal Tumors: A Systematic Review and Meta-Analysis. Front Oncol. 2021; 11:680842. PMC: 8222682. DOI: 10.3389/fonc.2021.680842. View

10.

Abel E, Linder B, Bauman T, Bauer R, Thompson R, Thapa P . Perioperative blood transfusion and radical cystectomy: does timing of transfusion affect bladder cancer mortality?. Eur Urol. 2014; 66(6):1139-47. DOI: 10.1016/j.eururo.2014.08.051. View

11.

Cata J, Wang H, Gottumukkala V, Reuben J, Sessler D . Inflammatory response, immunosuppression, and cancer recurrence after perioperative blood transfusions. Br J Anaesth. 2013; 110(5):690-701. PMC: 3630286. DOI: 10.1093/bja/aet068. View

12.

M E L Henderickx M, Baldew S, Marconi L, van Dijk M, van Etten-Jamaludin F, Lagerveld B . Surgical margins after partial nephrectomy as prognostic factor for the risk of local recurrence in pT1 RCC: a systematic review and narrative synthesis. World J Urol. 2022; 40(9):2169-2179. PMC: 9427912. DOI: 10.1007/s00345-022-04016-0. View

13.

Curet M . Port site metastases. Am J Surg. 2004; 187(6):705-12. DOI: 10.1016/j.amjsurg.2003.10.015. View

14.

Kutikov A, Uzzo R . The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 2009; 182(3):844-53. DOI: 10.1016/j.juro.2009.05.035. View

15.

Yoshino H, Miyamoto K, Hwang E, Yamane T, Nakagawa M, Enokida H . Is It Safe to Use the Same Scissors After Accidental Tumor Incision During Partial Nephrectomy? Results of In Vitro and In Vivo Experiments. J Endourol. 2017; 31(4):391-395. DOI: 10.1089/end.2016.0848. View

16.

Maxwell A, Baird G, Iannuccilli J, Mayo-Smith W, Dupuy D . Renal Cell Carcinoma: Comparison of RENAL Nephrometry and PADUA Scores with Maximum Tumor Diameter for Prediction of Local Recurrence after Thermal Ablation. Radiology. 2016; 283(2):590-597. DOI: 10.1148/radiol.2016161225. View

17.

Mir M, Derweesh I, Porpiglia F, Zargar H, Mottrie A, Autorino R . Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies. Eur Urol. 2016; 71(4):606-617. DOI: 10.1016/j.eururo.2016.08.060. View

18.

Wan J, Zhu L, Jiang Z, Cheng K . Monitoring of plasma cell-free DNA in predicting postoperative recurrence of clear cell renal cell carcinoma. Urol Int. 2013; 91(3):273-8. DOI: 10.1159/000351409. View

19.

Linder B, Frank I, Cheville J, Tollefson M, Thompson R, Tarrell R . The impact of perioperative blood transfusion on cancer recurrence and survival following radical cystectomy. Eur Urol. 2013; 63(5):839-45. DOI: 10.1016/j.eururo.2013.01.004. View

20.

Li G, Zhi C, Zhu D, Liu Z, Niu Y . Efficacy of povidone-iodine against accidental tumor incision during nephron-sparing surgery: experimental study in patients with renal cell carcinoma. J Int Med Res. 2019; 47(10):4993-5002. PMC: 6997783. DOI: 10.1177/0300060519874155. View