Effects of Group Exercise Intervention on Quality of Life and Physical Parameters in Patients with Childhood Cancer: A Systematic Review

Overview

Journal Curr Oncol

Publisher MDPI

Specialty Oncology

Date 2024 Feb 23

PMID 38392071

Authors

Yurina Doi

Masato Ogawa

Kodai Ishihara

Junichiro Inoue

Kazuhiro P Izawa

Affiliations

Soon will be listed here.

Abstract

Background: Although the survival rates of childhood cancer are increasing, children diagnosed as having cancer experience psychological and physical problems and a declining quality of life (QOL).

Methods: A systematic review of PubMed databases was conducted up to September 2023 to identify studies reporting the effects of group exercise intervention in children with cancer. The inclusion criteria were pre-specified, including children aged ≤19 years old who received group exercise intervention and interventional studies written in English. Studies involving non-exercise intervention or non-group intervention were excluded.

Results: Five studies were included in the present review. In three studies, QOL and physical parameters were improved after group exercise intervention, and in two studies, only physical parameters were improved. Improvements in QOL were achieved through psychosocial variables, improved scores of subscales of pain and hurt, nausea, and procedure-related anxiety, and reduced cancer-related fatigue. All studies had high numbers of participants who completed the intervention. However, all studies showed a high risk of bias regarding the selection of the reported results, and most studies showed a high risk of bias regarding deviations from the intended intervention and outcome measurement.

Conclusion: The reviewed studies showed that group exercise intervention for children with cancer could improve their QOL and/or physical parameters.

References

Perondi M, Gualano B, Artioli G, de Salles Painelli V, Filho V, Netto G . Effects of a combined aerobic and strength training program in youth patients with acute lymphoblastic leukemia. J Sports Sci Med. 2013; 11(3):387-92. PMC: 3737942. View

Varni J, Burwinkle T, Seid M . The PedsQL as a pediatric patient-reported outcome: reliability and validity of the PedsQL Measurement Model in 25,000 children. Expert Rev Pharmacoecon Outcomes Res. 2009; 5(6):705-19. DOI: 10.1586/14737167.5.6.705. View

Braam K, van Dijk-Lokkart E, Kaspers G, Takken T, Huisman J, Bierings M . Cardiorespiratory fitness and physical activity in children with cancer. Support Care Cancer. 2015; 24(5):2259-2268. PMC: 4805718. DOI: 10.1007/s00520-015-2993-1. View

Braam K, van Dijk-Lokkart E, Kaspers G, Takken T, Huisman J, Buffart L . Effects of a combined physical and psychosocial training for children with cancer: a randomized controlled trial. BMC Cancer. 2018; 18(1):1289. PMC: 6307314. DOI: 10.1186/s12885-018-5181-0. View

Robison L, Hudson M . Survivors of childhood and adolescent cancer: life-long risks and responsibilities. Nat Rev Cancer. 2013; 14(1):61-70. PMC: 6425479. DOI: 10.1038/nrc3634. View

Li H, Lopez V, Chung O, Ho K, Chiu S . The impact of cancer on the physical, psychological and social well-being of childhood cancer survivors. Eur J Oncol Nurs. 2012; 17(2):214-9. DOI: 10.1016/j.ejon.2012.07.010. View

Sterne J, Savovic J, Page M, Elbers R, Blencowe N, Boutron I . RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ. 2019; 366:l4898. DOI: 10.1136/bmj.l4898. View

Li W, Ho K, Lam K, Lam H, Chui S, Chan G . Adventure-based training to promote physical activity and reduce fatigue among childhood cancer survivors: A randomized controlled trial. Int J Nurs Stud. 2018; 83:65-74. DOI: 10.1016/j.ijnurstu.2018.04.007. View

Yildiz Kabak V, Calders P, Duger T, Mohammed J, van Breda E . Short and long-term impairments of cardiopulmonary fitness level in previous childhood cancer cases: a systematic review. Support Care Cancer. 2018; 27(1):69-86. DOI: 10.1007/s00520-018-4483-8. View

10.

Ho L, Li W, Cheung A, Ho E, Lam K, Chiu S . Relationships among hope, psychological well-being and health-related quality of life in childhood cancer survivors. J Health Psychol. 2019; 26(10):1528-1537. DOI: 10.1177/1359105319882742. View

11.

McCaffrey C . Major stressors and their effects on the well-being of children with cancer. J Pediatr Nurs. 2006; 21(1):59-66. DOI: 10.1016/j.pedn.2005.07.003. View

12.

Tonorezos E, Ford J, Wang L, Ness K, Yasui Y, Leisenring W . Impact of exercise on psychological burden in adult survivors of childhood cancer: A report from the Childhood Cancer Survivor Study. Cancer. 2019; 125(17):3059-3067. PMC: 6690787. DOI: 10.1002/cncr.32173. View

13.

Antwi G, Jayawardene W, Lohrmann D, Mueller E . Physical activity and fitness among pediatric cancer survivors: a meta-analysis of observational studies. Support Care Cancer. 2019; 27(9):3183-3194. DOI: 10.1007/s00520-019-04788-z. View

14.

Liberati A, Altman D, Tetzlaff J, Mulrow C, Gotzsche P, Ioannidis J . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ. 2009; 339:b2700. PMC: 2714672. DOI: 10.1136/bmj.b2700. View

15.

Gotte M, Kesting S, Winter C, Rosenbaum D, Boos J . Experience of barriers and motivations for physical activities and exercise during treatment of pediatric patients with cancer. Pediatr Blood Cancer. 2014; 61(9):1632-7. DOI: 10.1002/pbc.25071. View

16.

Hartman A, van den Bos C, Stijnen T, Pieters R . Decrease in peripheral muscle strength and ankle dorsiflexion as long-term side effects of treatment for childhood cancer. Pediatr Blood Cancer. 2007; 50(4):833-7. DOI: 10.1002/pbc.21325. View

17.

Hartman A, te Winkel M, van Beek R, de Muinck Keizer-Schrama S, Kemper H, Hop W . A randomized trial investigating an exercise program to prevent reduction of bone mineral density and impairment of motor performance during treatment for childhood acute lymphoblastic leukemia. Pediatr Blood Cancer. 2009; 53(1):64-71. DOI: 10.1002/pbc.21942. View

18.

Masoud A, Shaheen A, Algabbani M, AlEisa E, AlKofide A . Effectiveness of exergaming in reducing cancer-related fatigue among children with acute lymphoblastic leukemia: a randomized controlled trial. Ann Med. 2023; 55(1):2224048. PMC: 10274562. DOI: 10.1080/07853890.2023.2224048. View

19.

Marchese V, Chiarello L, Lange B . Effects of physical therapy intervention for children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2004; 42(2):127-33. DOI: 10.1002/pbc.10481. View

20.

Larsen E, Mellblom A, Larsen M, Ruud E, Thorsen L, Petersen N . Perceived barriers and facilitators to physical activity in childhood cancer survivors and their parents: A large-scale interview study from the International PACCS Study. Pediatr Blood Cancer. 2022; 70(1):e30056. DOI: 10.1002/pbc.30056. View