Short and Long-term Impairments of Cardiopulmonary Fitness Level in Previous Childhood Cancer Cases: a Systematic Review

Overview

Journal Support Care Cancer

Specialties Critical Care
Oncology

Date 2018 Sep 26

PMID 30251066

Citations 17

Authors

Vesile Yildiz Kabak

Patrick Calders

Tulin Duger

Jibril Mohammed

Eric van Breda

Affiliations

Soon will be listed here.

Abstract

Purpose: To describe the impairments in physical fitness in individuals who were previously diagnosed and treated for childhood cancer.

Methods: Using the PRISMA-guidelines, a systematic search was performed in PubMed, Web of Science, and Embase using a combination of the following predefined keywords: "exercise capacity" OR "aerobic capacity" OR "fitness" OR "cardiorespiratory fitness" OR "cardiopulmonary fitness" OR "physical fitness" OR "exercise testing" OR "exercise tolerance" OR "exercise" OR "oxygen consumption" AND "leukemia" OR "childhood cancer" OR "childhood cancer survivors (CCS)". Studies that met our inclusion criteria were reviewed on methodological quality, while the Newcastle-Ottawa Scale was used for evidence synthesis.

Results: A total of 2644 articles were identified from the database search. After screening based on the eligibility (abstracts) and inclusion (full texts) criteria, 49 articles remained. Even though the risk-of-bias scores in the studies were generally low, yet the results from those with high-quality studies revealed that poor fitness levels were prevalent in individuals with acute lymphoblastic leukemia, brain tumor, and mixed cancer histories, compared to healthy controls.

Conclusions: A global glance at CCS shows poor levels of fitness that is continuous and life-long even after active cancer treatment has ended. Nevertheless, the results presented in this review were based on a limited number of high-quality studies suggesting the need to for additional clinical trials in the topic area.

Citing Articles

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Reliability and validity of self-report questions for assessing levels of physical activity and sedentary time in adult childhood cancer survivors.

Jess L, Jarfelt M, Back M BMC Sports Sci Med Rehabil. 2024; 16(1):66.

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Effects of Group Exercise Intervention on Quality of Life and Physical Parameters in Patients with Childhood Cancer: A Systematic Review.

Doi Y, Ogawa M, Ishihara K, Inoue J, Izawa K Curr Oncol. 2024; 31(2):1035-1046.

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Children with cancer and their cardiorespiratory fitness and physical function-the long-term effects of a physical activity program during treatment: a multicenter non-randomized controlled trial.

Fridh M, Schmidt-Andersen P, Andres-Jensen L, Thorsteinsson T, Wehner P, Hasle H J Cancer Surviv. 2023; .

PMID: 38057671 DOI: 10.1007/s11764-023-01499-7.

Surveillance cardiopulmonary exercise testing can risk-stratify childhood cancer survivors: underlying pathophysiology of poor exercise performance and possible room for improvement.

Tsuda T, Davidow K, DAloisio G, Quillen J Cardiooncology. 2023; 9(1):42.

PMID: 37978571 PMC: 10655267. DOI: 10.1186/s40959-023-00193-y.

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