Nutrient Metabolism in Regulating Intestinal Stem Cell Homeostasis

Overview

Journal Cell Prolif

Date 2024 Feb 22

PMID 38386338

Authors

Ruicheng Shi

Bo Wang

Affiliations

Soon will be listed here.

Abstract

Intestinal stem cells (ISCs) are known for their remarkable proliferative capacity, making them one of the most active cell populations in the body. However, a high turnover rate of intestinal epithelium raises the likelihood of dysregulated homeostasis, which is known to cause various diseases, including cancer. Maintaining precise control over the homeostasis of ISCs is crucial to preserve the intestinal epithelium's integrity during homeostasis or stressed conditions. Recent research has indicated that nutrients and metabolic pathways can extensively modulate the fate of ISCs. This review will explore recent findings concerning the influence of various nutrients, including lipids, carbohydrates, and vitamin D, on the delicate balance between ISC proliferation and differentiation.

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