Brain-derived Neurotrophic Factor (BDNF) Levels in Panic Disorder: A Systematic Review and Meta-analysis

Overview

Journal Brain Behav

Specialty Psychology

Date 2024 Feb 20

PMID 38376041

Authors

Arman Shafiee

Kyana Jafarabady

Ida Mohammadi

Shahryar Rajai

Affiliations

Soon will be listed here.

Abstract

Background: The existing literature on the association between brain-derived neurotrophic factor (BDNF) protein levels and panic disorder presents inconsistent findings. This systematic review and meta-analysis aim to synthesize the available evidence and determine the overall effect of BDNF protein levels in individuals diagnosed with panic disorder.

Methods: A comprehensive literature search was conducted using electronic databases (PubMed, Embase, Scopus, PsycINFO, and Web of Science) from inception to April 21, 2023. The search strategy included relevant keywords and medical subject headings terms related to BDNF, panic disorder, and protein levels. A random-effects model was used for the meta-analysis, and subgroup analyses were performed to explore heterogeneity. Publication bias was assessed using funnel plots and statistical tests.

Results: A total of 12 studies met the inclusion criteria. The meta-analysis demonstrated a significant decrease in BDNF protein levels in individuals with panic disorder (SMD = -.53, 95% CI: -1.02 to -.04, p < .001; I : 92%). The results of subgroup and meta-regression analyses were not statistically significant. No significant publication bias was observed based on the results of Egger's regression test (p-value = .3550).

Conclusion: This systematic review and meta-analysis provide evidence of lower BDNF protein levels in individuals diagnosed with panic disorder compared to healthy controls. The findings suggest a potential role for BDNF dysregulation in the pathophysiology of panic disorder. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.

Citing Articles

The Interrelationship Between ADHD and Panic Attacks: A Case Study and Comprehensive Literature Review.

Medghalchi N, Hassanzadeh Rad A, Zavar Mousavi M Iran J Child Neurol. 2025; 19(1):135-141.

PMID: 39896702 PMC: 11781337. DOI: 10.22037/ijcn.v19i1.46995.

Brain-derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta-analysis.

Shafiee A, Jafarabady K, Mohammadi I, Rajai S Brain Behav. 2024; 14(1):e3349.

PMID: 38376041 PMC: 10757897. DOI: 10.1002/brb3.3349.

References

Li Y, Li F, Qin D, Chen H, Wang J, Wang J . The role of brain derived neurotrophic factor in central nervous system. Front Aging Neurosci. 2022; 14:986443. PMC: 9493475. DOI: 10.3389/fnagi.2022.986443. View

Page M, McKenzie J, Bossuyt P, Boutron I, Hoffmann T, Mulrow C . The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021; 372:n71. PMC: 8005924. DOI: 10.1136/bmj.n71. View

Miranda M, Morici J, Zanoni M, Bekinschtein P . Brain-Derived Neurotrophic Factor: A Key Molecule for Memory in the Healthy and the Pathological Brain. Front Cell Neurosci. 2019; 13:363. PMC: 6692714. DOI: 10.3389/fncel.2019.00363. View

Maron E, Toru I, Maemets K, Sepp S, Vasar V, Shlik J . CCK-4-induced anxiety but not panic is associated with serum brain-derived neurotrophic factor in healthy subjects. J Psychopharmacol. 2008; 23(4):460-4. DOI: 10.1177/0269881108089600. View

Choi D, Maguschak K, Ye K, Jang S, Myers K, Ressler K . Prelimbic cortical BDNF is required for memory of learned fear but not extinction or innate fear. Proc Natl Acad Sci U S A. 2010; 107(6):2675-80. PMC: 2823921. DOI: 10.1073/pnas.0909359107. View

Chu L, Sun X, Jia X, Li D, Gao P, Zhang Y . The Relationship Among BDNF Val66Met Polymorphism, Plasma BDNF Level, and Trait Anxiety in Chinese Patients With Panic Disorder. Front Psychiatry. 2022; 13:932235. PMC: 9259790. DOI: 10.3389/fpsyt.2022.932235. View

Naert G, Ixart G, Maurice T, Tapia-Arancibia L, Givalois L . Brain-derived neurotrophic factor and hypothalamic-pituitary-adrenal axis adaptation processes in a depressive-like state induced by chronic restraint stress. Mol Cell Neurosci. 2010; 46(1):55-66. DOI: 10.1016/j.mcn.2010.08.006. View

An J, Jang E, Kim A, Fava M, Mischoulon D, Papakostas G . Ratio of plasma BDNF to leptin levels are associated with treatment response in major depressive disorder but not in panic disorder: A 12-week follow-up study. J Affect Disord. 2019; 259:349-354. DOI: 10.1016/j.jad.2019.08.021. View

Bekinschtein P, von Bohlen Und Halbach O . Editorial: Cellular and Molecular Mechanisms of Neurotrophin Function in the Nervous System. Front Cell Neurosci. 2020; 14:101. PMC: 7198694. DOI: 10.3389/fncel.2020.00101. View

10.

Xia Y, Song X, Wu L, Li J, Liu N, Cui W . Pathoclinical associations between panic disorders and the brain-derived neurotrophic factor Val66Met polymorphism: an updated meta-analysis. Psychiatr Genet. 2023; 33(2):50-58. PMC: 9997625. DOI: 10.1097/YPG.0000000000000337. View

11.

Colucci-DAmato L, Speranza L, Volpicelli F . Neurotrophic Factor BDNF, Physiological Functions and Therapeutic Potential in Depression, Neurodegeneration and Brain Cancer. Int J Mol Sci. 2020; 21(20). PMC: 7589016. DOI: 10.3390/ijms21207777. View

12.

Li R, Li J, Liu Y, Li D, Chu L, Zhang J . Serum BDNF levels are involved in the diagnosis and treatment response in patients with PD. J Affect Disord. 2023; 327:31-37. DOI: 10.1016/j.jad.2023.01.107. View

13.

Chen S, Jiang H, Liu Y, Hou Z, Yue Y, Zhang Y . Combined serum levels of multiple proteins in tPA-BDNF pathway may aid the diagnosis of five mental disorders. Sci Rep. 2017; 7(1):6871. PMC: 5537244. DOI: 10.1038/s41598-017-06832-6. View

14.

Alleva E, Francia N . Psychiatric vulnerability: suggestions from animal models and role of neurotrophins. Neurosci Biobehav Rev. 2008; 33(4):525-36. DOI: 10.1016/j.neubiorev.2008.09.004. View

15.

Shafiee A, Jafarabady K, Mohammadi I, Rajai S . Brain-derived neurotrophic factor (BDNF) levels in panic disorder: A systematic review and meta-analysis. Brain Behav. 2024; 14(1):e3349. PMC: 10757897. DOI: 10.1002/brb3.3349. View

16.

Abelson J, Curtis G . Hypothalamic-pituitary-adrenal axis activity in panic disorder. 24-hour secretion of corticotropin and cortisol. Arch Gen Psychiatry. 1996; 53(4):323-31. DOI: 10.1001/archpsyc.1996.01830040059010. View

17.

Dincheva I, Lynch N, Lee F . The Role of BDNF in the Development of Fear Learning. Depress Anxiety. 2016; 33(10):907-916. PMC: 5089164. DOI: 10.1002/da.22497. View

18.

Bathina S, Das U . Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci. 2016; 11(6):1164-78. PMC: 4697050. DOI: 10.5114/aoms.2015.56342. View

19.

Wang W, Liu Y, Luo S, Guo X, Luo X, Zhang Y . Associations between brain-derived neurotrophic factor and cognitive impairment in panic disorder. Brain Behav. 2020; 10(12):e01885. PMC: 7749616. DOI: 10.1002/brb3.1885. View

20.

Psotta L, Lessmann V, Endres T . Impaired fear extinction learning in adult heterozygous BDNF knock-out mice. Neurobiol Learn Mem. 2013; 103:34-8. DOI: 10.1016/j.nlm.2013.03.003. View