Mechanism and Role of Mitophagy in the Development of Severe Infection

Overview

Journal Cell Death Discov

Date 2024 Feb 19

PMID 38374038

Authors

Lixiu Ma

Tianyu Han

Yi-An Zhan

Affiliations

Soon will be listed here.

Abstract

Mitochondria produce adenosine triphosphate and potentially contribute to proinflammatory responses and cell death. Mitophagy, as a conservative phenomenon, scavenges waste mitochondria and their components in the cell. Recent studies suggest that severe infections develop alongside mitochondrial dysfunction and mitophagy abnormalities. Restoring mitophagy protects against excessive inflammation and multiple organ failure in sepsis. Here, we review the normal mitophagy process, its interaction with invading microorganisms and the immune system, and summarize the mechanism of mitophagy dysfunction during severe infection. We highlight critical role of normal mitophagy in preventing severe infection.

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