Cellular Mitophagy: Mechanism, Roles in Diseases and Small Molecule Pharmacological Regulation

Overview

Journal Theranostics

Date 2023 Jan 12

PMID 36632220

Authors

Yingying Lu

Zhijia Li

Shuangqian Zhang

Tongtong Zhang

Yanjun Liu

Lan Zhang

Affiliations

Soon will be listed here.

Abstract

Cellular mitophagy means that cells selectively wrap and degrade damaged mitochondria through an autophagy mechanism, thus maintaining mitochondria and intracellular homeostasis. In recent years, mitophagy has received increasing attention as a research hotspot related to the pathogenesis of clinical diseases, such as neurodegenerative diseases, cardiovascular diseases, cancer, metabolic diseases, and so on. It has been found that the regulation of mitophagy may become a new direction for the treatment of some diseases. In addition, numerous small molecule modulators of mitophagy have also been reported, which provides new opportunities to comprehend the procedure and potential of therapeutic development. Taken together, in this review, we summarize current understanding of the mechanism of mitophagy, discuss the roles of mitophagy and its relationship with diseases, introduce the existing small-molecule pharmacological modulators of mitophagy and further highlight the significance of their development.

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