Advancing Burn Wound Treatment: Exploring Hydrogel As a Transdermal Drug Delivery System

Overview

Journal Drug Deliv

Specialty Pharmacology

Date 2024 Feb 17

PMID 38366562

Authors

MeeiChyn Goh

Meng Du

Wang Rui Peng

Phei Er Saw

Zhiyi Chen

Affiliations

Soon will be listed here.

Abstract

Burn injuries are prevalent and life-threatening forms that contribute significantly to mortality rates due to associated wound infections. The management of burn wounds presents substantial challenges. Hydrogel exhibits tremendous potential as an ideal alternative to traditional wound dressings such as gauze. This is primarily attributed to its three-dimensional (3D) crosslinked polymer network, which possesses a high water content, fostering a moist environment that supports effective burn wound healing. Additionally, hydrogel facilitates the penetration of loaded therapeutic agents throughout the wound surface, combating burn wound pathogens through the hydration effect and thereby enhancing the healing process. However, the presence of eschar formation on burn wounds obstructs the passive diffusion of therapeutics, impairing the efficacy of hydrogel as a wound dressing, particularly in cases of severe burns involving deeper tissue damage. This review focuses on exploring the potential of hydrogel as a carrier for transdermal drug delivery in burn wound treatment. Furthermore, strategies aimed at enhancing the transdermal delivery of therapeutic agents from hydrogel to optimize burn wound healing are also discussed.

Citing Articles

Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings.

Alberts A, Tudorache D, Niculescu A, Grumezescu A Gels. 2025; 11(2).

PMID: 39996666 PMC: 11854827. DOI: 10.3390/gels11020123.

Hydrogel systems for spatiotemporal controlled delivery of immunomodulators: engineering the tumor immune microenvironment for enhanced cancer immunotherapy.

Liu Y, Liu F, Zeng Y, Lin L, Yu H, Zhang S Front Cell Dev Biol. 2024; 12:1514595.

PMID: 39735340 PMC: 11681625. DOI: 10.3389/fcell.2024.1514595.

Skin Structure, Physiology, and Pathology in Topical and Transdermal Drug Delivery.

Brito S, Baek M, Bin B Pharmaceutics. 2024; 16(11).

PMID: 39598527 PMC: 11597055. DOI: 10.3390/pharmaceutics16111403.

Nanoparticle-Based Therapeutics for Enhanced Burn Wound Healing: A Comprehensive Review.

Shi S, Ou X, Long J, Lu X, Xu S, Zhang L Int J Nanomedicine. 2024; 19:11213-11233.

PMID: 39513089 PMC: 11542498. DOI: 10.2147/IJN.S490027.

Hydrogels with Essential Oils: Recent Advances in Designs and Applications.

Chelu M Gels. 2024; 10(10).

PMID: 39451288 PMC: 11508064. DOI: 10.3390/gels10100636.

References

Gupta A, Low W, Radecka I, Britland S, Amin M, Martin C . Characterisation and in vitro antimicrobial activity of biosynthetic silver-loaded bacterial cellulose hydrogels. J Microencapsul. 2016; 33(8):725-734. DOI: 10.1080/02652048.2016.1253796. View

Lenfant F, Lahet J, Courderot-Masuyer C, Freysz M, Rochette L . Lidocaine has better antioxidant potential than ropivacaine and bupivacaine: in vitro comparison in a model of human erythrocytes submitted to an oxidative stress. Biomed Pharmacother. 2004; 58(4):248-54. DOI: 10.1016/j.biopha.2003.12.013. View

Mai B, Jia M, Liu S, Sheng Z, Li M, Gao Y . Smart Hydrogel-Based DVDMS/bFGF Nanohybrids for Antibacterial Phototherapy with Multiple Damaging Sites and Accelerated Wound Healing. ACS Appl Mater Interfaces. 2020; 12(9):10156-10169. DOI: 10.1021/acsami.0c00298. View

Dhivya S, Vijaya Padma V, Santhini E . Wound dressings - a review. Biomedicine (Taipei). 2015; 5(4):22. PMC: 4662938. DOI: 10.7603/s40681-015-0022-9. View

Johnson N, Wang Y . Drug delivery systems for wound healing. Curr Pharm Biotechnol. 2015; 16(7):621-9. PMC: 6053062. DOI: 10.2174/1389201016666150206113720. View

Pan Z, Ye H, Wu D . Recent advances on polymeric hydrogels as wound dressings. APL Bioeng. 2021; 5(1):011504. PMC: 7889296. DOI: 10.1063/5.0038364. View

Chen X, Zhang H, Yang X, Zhang W, Jiang M, Wen T . Preparation and Application of Quaternized Chitosan- and AgNPs-Base Synergistic Antibacterial Hydrogel for Burn Wound Healing. Molecules. 2021; 26(13). PMC: 8271850. DOI: 10.3390/molecules26134037. View

Shabatina T, Vernaya O, Shumilkin A, Semenov A, Melnikov M . Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications. Materials (Basel). 2022; 15(10). PMC: 9147160. DOI: 10.3390/ma15103602. View

Klinkajon W, Supaphol P . Novel copper (II) alginate hydrogels and their potential for use as anti-bacterial wound dressings. Biomed Mater. 2014; 9(4):045008. DOI: 10.1088/1748-6041/9/4/045008. View

10.

Church D, Elsayed S, Reid O, Winston B, Lindsay R . Burn wound infections. Clin Microbiol Rev. 2006; 19(2):403-34. PMC: 1471990. DOI: 10.1128/CMR.19.2.403-434.2006. View

11.

Martinez-Higuera A, Rodriguez-Beas C, Villalobos-Noriega J, Arizmendi-Grijalva A, Ochoa-Sanchez C, Larios-Rodriguez E . Hydrogel with silver nanoparticles synthesized by Mimosa tenuiflora for second-degree burns treatment. Sci Rep. 2021; 11(1):11312. PMC: 8163746. DOI: 10.1038/s41598-021-90763-w. View

12.

Zia T, Usman M, Sabir A, Shafiq M, Khan R . Development of inter-polymeric complex of anionic polysaccharides, alginate/k-carrageenan bio-platform for burn dressing. Int J Biol Macromol. 2020; 157:83-95. DOI: 10.1016/j.ijbiomac.2020.04.157. View

13.

Wilkinson L, White R, Chipman J . Silver and nanoparticles of silver in wound dressings: a review of efficacy and safety. J Wound Care. 2012; 20(11):543-9. DOI: 10.12968/jowc.2011.20.11.543. View

14.

Wang M, Huang X, Zheng H, Tang Y, Zeng K, Shao L . Nanomaterials applied in wound healing: Mechanisms, limitations and perspectives. J Control Release. 2021; 337:236-247. DOI: 10.1016/j.jconrel.2021.07.017. View

15.

Yin C, Han X, Lu Q, Qi X, Guo C, Wu X . Rhein incorporated silk fibroin hydrogels with antibacterial and anti-inflammatory efficacy to promote healing of bacteria-infected burn wounds. Int J Biol Macromol. 2022; 201:14-19. DOI: 10.1016/j.ijbiomac.2021.12.156. View

16.

Shao X, Yang X, Zhou Y, Xia Q, Lu Y, Yan X . Antibacterial, wearable, transparent tannic acid-thioctic acid-phytic acid hydrogel for adhesive bandages. Soft Matter. 2022; 18(14):2814-2828. DOI: 10.1039/d2sm00058j. View

17.

Goel A, Shrivastava P . Post-burn scars and scar contractures. Indian J Plast Surg. 2011; 43(Suppl):S63-71. PMC: 3038392. DOI: 10.4103/0970-0358.70724. View

18.

Barrett L, Fear V, Waithman J, Wood F, Fear M . Understanding acute burn injury as a chronic disease. Burns Trauma. 2019; 7:23. PMC: 6745803. DOI: 10.1186/s41038-019-0163-2. View

19.

Zhu L, Chen L . Facile design and development of nano-clustery graphene-based macromolecular protein hydrogel loaded with ciprofloxacin to antibacterial improvement for the treatment of burn wound injury. Polym Bull (Berl). 2021; 79(9):7953-7968. PMC: 8454009. DOI: 10.1007/s00289-021-03875-8. View

20.

Yuan M, Liu K, Jiang T, Li S, Chen J, Wu Z . GelMA/PEGDA microneedles patch loaded with HUVECs-derived exosomes and Tazarotene promote diabetic wound healing. J Nanobiotechnology. 2022; 20(1):147. PMC: 8934449. DOI: 10.1186/s12951-022-01354-4. View