Drug Delivery Systems for Wound Healing

Overview

Journal Curr Pharm Biotechnol

Publisher Bentham Science Publishers

Specialties Biotechnology
Pharmacology

Date 2015 Feb 7

PMID 25658378

Citations 21

Authors

Noah R Johnson

Yadong Wang

Affiliations

Soon will be listed here.

Abstract

Protein, gene, and small molecule therapies hold great potential for facilitating comprehensive tissue repair and regeneration. However, their clinical value will rely on effective delivery systems which maximize their therapeutic benefit. Significant advances have been made in recent years towards biomaterial delivery systems to satisfy this clinical need. Here we summarize the most outstanding advances in drug delivery technology for cutaneous wound healing.

Citing Articles

Transforming Medicine: Cutting-Edge Applications of Nanoscale Materials in Drug Delivery.

Tenchov R, Hughes K, Ganesan M, Iyer K, Ralhan K, Lotti Diaz L ACS Nano. 2025; 19(4):4011-4038.

PMID: 39823199 PMC: 11803921. DOI: 10.1021/acsnano.4c09566.

Cannabinoids in Integumentary Wound Care: A Systematic Review of Emerging Preclinical and Clinical Evidence.

Niyangoda D, Muayad M, Tesfaye W, Bushell M, Ahmad D, Samarawickrema I Pharmaceutics. 2024; 16(8).

PMID: 39204426 PMC: 11359183. DOI: 10.3390/pharmaceutics16081081.

Recent advances in molecular mechanisms of skin wound healing and its treatments.

Al Mamun A, Shao C, Geng P, Wang S, Xiao J Front Immunol. 2024; 15:1395479.

PMID: 38835782 PMC: 11148235. DOI: 10.3389/fimmu.2024.1395479.

Sustainable Silk-Based Particulate Systems for the Controlled Release of Pharmaceuticals and Bioactive Agents in Wound Healing and Skin Regeneration.

Bernardes B, Veiga A, Barros J, Garcia-Gonzalez C, Oliveira A Int J Mol Sci. 2024; 25(6).

PMID: 38542108 PMC: 10970104. DOI: 10.3390/ijms25063133.

Advancing burn wound treatment: exploring hydrogel as a transdermal drug delivery system.

Goh M, Du M, Peng W, Saw P, Chen Z Drug Deliv. 2024; 31(1):2300945.

PMID: 38366562 PMC: 10878343. DOI: 10.1080/10717544.2023.2300945.

References

Guo R, Xu S, Ma L, Huang A, Gao C . The healing of full-thickness burns treated by using plasmid DNA encoding VEGF-165 activated collagen-chitosan dermal equivalents. Biomaterials. 2010; 32(4):1019-31. DOI: 10.1016/j.biomaterials.2010.08.087. View

Yang H, Shin J, Bhang S, Shin J, Park J, Im G . Enhanced skin wound healing by a sustained release of growth factors contained in platelet-rich plasma. Exp Mol Med. 2011; 43(11):622-9. PMC: 3249588. DOI: 10.3858/emm.2011.43.11.070. View

Lee K, Johnson N, Gao J, Wang Y . Human progenitor cell recruitment via SDF-1α coacervate-laden PGS vascular grafts. Biomaterials. 2013; 34(38):9877-85. PMC: 3882008. DOI: 10.1016/j.biomaterials.2013.08.082. View

Hong S, Lee S, Shim J, Choi Y, Lee Y, Song K . Study on gelatin-containing artificial skin IV: A comparative study on the effect of antibiotic and EGF on cell proliferation during epidermal healing. Biomaterials. 2001; 22(20):2777-83. DOI: 10.1016/s0142-9612(01)00021-7. View

Trentin D, Hall H, Wechsler S, Hubbell J . Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Proc Natl Acad Sci U S A. 2006; 103(8):2506-11. PMC: 1413769. DOI: 10.1073/pnas.0505964102. View

Sill T, von Recum H . Electrospinning: applications in drug delivery and tissue engineering. Biomaterials. 2008; 29(13):1989-2006. DOI: 10.1016/j.biomaterials.2008.01.011. View

Huang S, Deng T, Wu H, Chen F, Jin Y . Wound dressings containing bFGF-impregnated microspheres. J Microencapsul. 2006; 23(3):277-90. DOI: 10.1080/02652040500435170. View

Kanda N, Morimoto N, Takemoto S, Ayvazyan A, Kawai K, Sakamoto Y . Efficacy of novel collagen/gelatin scaffold with sustained release of basic fibroblast growth factor for dermis-like tissue regeneration. Ann Plast Surg. 2011; 69(5):569-74. DOI: 10.1097/SAP.0b013e318222832f. View

Singer A, Clark R . Cutaneous wound healing. N Engl J Med. 1999; 341(10):738-46. DOI: 10.1056/NEJM199909023411006. View

10.

Schultz G, Wysocki A . Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen. 2009; 17(2):153-62. DOI: 10.1111/j.1524-475X.2009.00466.x. View

11.

Yang Y, Xia T, Zhi W, Wei L, Weng J, Zhang C . Promotion of skin regeneration in diabetic rats by electrospun core-sheath fibers loaded with basic fibroblast growth factor. Biomaterials. 2011; 32(18):4243-54. DOI: 10.1016/j.biomaterials.2011.02.042. View

12.

Porporato P, Payen V, De Saedeleer C, Preat V, Thissen J, Feron O . Lactate stimulates angiogenesis and accelerates the healing of superficial and ischemic wounds in mice. Angiogenesis. 2012; 15(4):581-92. DOI: 10.1007/s10456-012-9282-0. View

13.

Kulkarni M, OLoughlin A, Vazquez R, Mashayekhi K, Rooney P, Greiser U . Use of a fibrin-based system for enhancing angiogenesis and modulating inflammation in the treatment of hyperglycemic wounds. Biomaterials. 2013; 35(6):2001-10. DOI: 10.1016/j.biomaterials.2013.11.003. View

14.

Pandit A, Feldman D, Caulfield J, Thompson A . Stimulation of angiogenesis by FGF-1 delivered through a modified fibrin scaffold. Growth Factors. 1998; 15(2):113-23. DOI: 10.3109/08977199809117187. View

15.

Hollier B, Harkin D, Leavesley D, Upton Z . Responses of keratinocytes to substrate-bound vitronectin: growth factor complexes. Exp Cell Res. 2005; 305(1):221-32. DOI: 10.1016/j.yexcr.2005.01.004. View

16.

Smith J, Moshref A, Jennings J, Courtney H, Haggard W . Chitosan sponges for local synergistic infection therapy: a pilot study. Clin Orthop Relat Res. 2013; 471(10):3158-64. PMC: 3773141. DOI: 10.1007/s11999-013-2988-5. View

17.

Hardwicke J, Ferguson E, Moseley R, Stephens P, Thomas D, Duncan R . Dextrin-rhEGF conjugates as bioresponsive nanomedicines for wound repair. J Control Release. 2008; 130(3):275-83. DOI: 10.1016/j.jconrel.2008.07.023. View

18.

Glowacki J, Mizuno S . Collagen scaffolds for tissue engineering. Biopolymers. 2007; 89(5):338-44. DOI: 10.1002/bip.20871. View

19.

Obara K, Ishihara M, Ishizuka T, Fujita M, Ozeki Y, Maehara T . Photocrosslinkable chitosan hydrogel containing fibroblast growth factor-2 stimulates wound healing in healing-impaired db/db mice. Biomaterials. 2003; 24(20):3437-44. DOI: 10.1016/s0142-9612(03)00220-5. View

20.

Moura L, Dias A, Leal E, Carvalho L, de Sousa H, Carvalho E . Chitosan-based dressings loaded with neurotensin--an efficient strategy to improve early diabetic wound healing. Acta Biomater. 2013; 10(2):843-57. DOI: 10.1016/j.actbio.2013.09.040. View