Interactions Between CNS and Immune Cells in Tuberculous Meningitis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Feb 16

PMID 38361935

Authors

Quan Ma

Jinyun Chen

Xingxing Kong

Yuqin Zeng

Zhanpeng Chen

Huazhen Liu

Lanlan Liu

Shuihua Lu

Xiaomin Wang

Affiliations

Soon will be listed here.

Abstract

The central nervous system (CNS) harbors its own special immune system composed of microglia in the parenchyma, CNS-associated macrophages (CAMs), dendritic cells, monocytes, and the barrier systems within the brain. Recently, advances in the immune cells in the CNS provided new insights to understand the development of tuberculous meningitis (TBM), which is the predominant form of () infection in the CNS and accompanied with high mortality and disability. The development of the CNS requires the protection of immune cells, including macrophages and microglia, during embryogenesis to ensure the accurate development of the CNS and immune response following pathogenic invasion. In this review, we summarize the current understanding on the CNS immune cells during the initiation and development of the TBM. We also explore the interactions of immune cells with the CNS in TBM. In the future, the combination of modern techniques should be applied to explore the role of immune cells of CNS in TBM.

Citing Articles

Epidemiology, Pathogenesis, Clinical Manifestations, and Management Strategies of Tuberculous Meningitis.

Oo N, Agrawal D Arch Intern Med Res. 2025; 8(1):48-58.

PMID: 40061519 PMC: 11887623. DOI: 10.26502/aimr.0195.

Ependymal cells: roles in central nervous system infections and therapeutic application.

Xie S, Li F J Neuroinflammation. 2024; 21(1):255.

PMID: 39385253 PMC: 11465851. DOI: 10.1186/s12974-024-03240-2.

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