Targeting Type H Vessels in Bone-related Diseases

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2024 Feb 14

PMID 38353470

Authors

Juan Xu

Shuang-Jian He

Ting-Ting Xia

Yu Shan

Liang Wang

Affiliations

Soon will be listed here.

Abstract

Blood vessels are essential for bone development and metabolism. Type H vessels in bone, named after their high expression of CD31 and Endomucin (Emcn), have recently been reported to locate mainly in the metaphysis, exhibit different molecular properties and couple osteogenesis and angiogenesis. A strong correlation between type H vessels and bone metabolism is now well-recognized. The crosstalk between type H vessels and osteoprogenitor cells is also involved in bone metabolism-related diseases such as osteoporosis, osteoarthritis, fracture healing and bone defects. Targeting the type H vessel formation may become a new approach for managing a variety of bone diseases. This review highlighted the roles of type H vessels in bone-related diseases and summarized the research attempts to develop targeted intervention, which will help us gain a better understanding of their potential value in clinical application.

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