Brain Artery Diameters and Risk of Dementia and Stroke

Overview

Journal Alzheimers Dement

Specialties Neurology
Psychiatry

Date 2024 Feb 9

PMID 38332543

Authors

Jesus D Melgarejo

Kursat Gurel

Cassidy Rose Compton

Minghua Liu

Vanessa Guzman

Stephanie Assuras

Bonnie E Levin

Mitchell S V Elkind

M Kamran Ikram

Maryam Kavousi

M Arfan Ikram

Clinton Wright

Fabrice Crivello

Alexandre Laurent

Christophe Tzourio

Meike W Vernooij

Tatjana Rundek

Zhen-Yu Zhang

Daniel Bos

Jose Gutierrez

Affiliations

Soon will be listed here.

Abstract

Introduction: We tested the association of brain artery diameters with dementia and stroke risk in three distinct population-based studies using conventional T2-weighted brain magnetic resonance imaging (MRI) images.

Methods: We included 8420 adults > 40 years old from three longitudinal population-based studies with brain MRI scans. We estimated and meta-analyzed the hazard ratios (HRs) of the brain and carotids and basilar diameters associated with dementia and stroke.

Result: Overall and carotid artery diameters > 95th percentile increased the risk for dementia by 1.74 (95% confidence interval [CI], 1.13-2.68) and 1.48 (95% CI, 1.12-1.96) fold, respectively. For stroke, meta-analyses yielded HRs of 1.59 (95% CI, 1.04-2.42) for overall arteries and 2.11 (95% CI, 1.45-3.08) for basilar artery diameters > 95th percentile.

Discussion: Individuals with dilated brain arteries are at higher risk for dementia and stroke, across distinct populations. Our findings underline the potential value of T2-weighted brain MRI-based brain diameter assessment in estimating the risk of dementia and stroke.

Citing Articles

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PMID: 39839306 PMC: 11747422. DOI: 10.3389/fnagi.2024.1445164.

Brain artery diameters and risk of dementia and stroke.

Melgarejo J, Gurel K, Compton C, Liu M, Guzman V, Assuras S Alzheimers Dement. 2024; 20(4):2497-2507.

PMID: 38332543 PMC: 11032539. DOI: 10.1002/alz.13712.

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