Movement Disorders Following Mechanical Thrombectomy Resulting in Ischemic Lesions of the Basal Ganglia: An Emerging Clinical Entity

Overview

Journal Eur J Neurol

Publisher Wiley

Specialty Neurology

Date 2024 Feb 1

PMID 38299441

Authors

Leonardo Rigon

Danilo Genovese

Carla Piano

Valerio Brunetti

Valeria Guglielmi

Angelo Tiziano Cimmino

Irene Scala

Salvatore Citro

Anna Rita Bentivoglio

Eleonora Rollo

Riccardo Di Iorio

Aldobrando Broccolini

Roberta Morosetti

Mauro Monforte

Giovanni Frisullo

Pietro Caliandro

Alessandro Pedicelli

Anselmo Caricato

Giovanna Masone

Paolo Calabresi

Giacomo Della Marca

Affiliations

Soon will be listed here.

Abstract

Background And Purpose: Post-stroke movement disorders (PMDs) following ischemic lesions of the basal ganglia (BG) are a known entity, but data regarding their incidence are lacking. Ischemic strokes secondary to proximal middle cerebral artery (MCA) occlusion treated with thrombectomy represent a model of selective damage to the BG. The aim of this study was to assess the prevalence and features of movement disorders after selective BG ischemia in patients with successfully reperfused acute ischemic stroke (AIS).

Methods: We enrolled 64 consecutive subjects with AIS due to proximal MCA occlusion treated with thrombectomy. Patients were clinically evaluated by a movement disorders specialist for PMDs onset at baseline, and after 6 and 12 months.

Results: None of the patients showed an identifiable movement disorder in the subacute phase of the stroke. At 6 and 12 months, respectively, 7/25 (28%) and 7/13 (53.8%) evaluated patients developed PMDs. The clinical spectrum of PMDs encompassed parkinsonism, dystonia and chorea, either isolated or combined. In most patients, symptoms were contralateral to the lesion, although a subset of patients presented with bilateral involvement and prominent axial signs.

Conclusion: Post-stroke movement disorders are not uncommon in long-term follow-up of successfully reperfused AIS. Follow-up conducted by a multidisciplinary team is strongly advisable in patients with selective lesions of the BG after AIS, even if asymptomatic at discharge.

Citing Articles

Movement disorders following mechanical thrombectomy resulting in ischemic lesions of the basal ganglia: An emerging clinical entity.

Rigon L, Genovese D, Piano C, Brunetti V, Guglielmi V, Cimmino A Eur J Neurol. 2024; 31(5):e16219.

PMID: 38299441 PMC: 11235728. DOI: 10.1111/ene.16219.

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