Dyslipidemia Among Patients with Ischemic Stroke Admitted to the Department of Medicine of a Tertiary Care Centre

Overview

Journal JNMA J Nepal Med Assoc

Specialty General Medicine

Date 2024 Jan 30

PMID 38289800

Authors

Tunam Khadka

Ganesh Kumar Giri

Pasang Sherpa

Urbi Ghimire

Shamin Parajuli

Ashok Pudasaini

Sajan Shrestha

Affiliations

Soon will be listed here.

Abstract

Introduction: Sudden neurological deficits due to an acute focal vascular injury of the central nervous system is stroke. It is a major cause of morbidity and mortality. Dyslipidemia is any abnormality in the parameter of the lipid profile which has been associated with stroke. The aim of this study was to find out the prevalence of dyslipidemia among patients with ischemic stroke in the Department of Medicine of a tertiary care centre.

Methods: A descriptive cross-sectional study was conducted in a tertiary care centre among admitted ischemic stroke patients from 5 August 2022 to 14 March 2023 after obtaining ethical approval from the Institutional Review Committee. Overnight fasting blood samples were collected for lipid profile. Convenience sampling method was used. The point estimate was calculated at a 95% Confidence Interval.

Results: Among 79 ischemic stroke patients, 42 (53.16%) (42.09-64.23, at 95% Confidence Interval) had dyslipidemia where high cholesterol was seen in 21 (50%), high triglyceride in 22 (52.38%), high low-density lipoprotein 14 (33.33%) and low high-density lipoprotein in 20 (47.61%).

Conclusions: The prevalence of dyslipidemia among ischemic stroke patients was lower than the similar studies done in similar settings.

Keywords: cross-sectional studies; dyslipidemia; hyperlipidemias; ischemic stroke.

References

Miya Shaik M, Loo K, Gan S . Burden of stroke in Nepal. Int J Stroke. 2012; 7(6):517-20. DOI: 10.1111/j.1747-4949.2012.00799.x. View

Saini V, Guada L, Yavagal D . Global Epidemiology of Stroke and Access to Acute Ischemic Stroke Interventions. Neurology. 2021; 97(20 Suppl 2):S6-S16. DOI: 10.1212/WNL.0000000000012781. View

Dalal P, Malik S, Bhattacharjee M, Trivedi N, Vairale J, Bhat P . Population-based stroke survey in Mumbai, India: incidence and 28-day case fatality. Neuroepidemiology. 2008; 31(4):254-61. DOI: 10.1159/000165364. View

Sarti C, Kaarisalo M, Tuomilehto J . The relationship between cholesterol and stroke: implications for antihyperlipidaemic therapy in older patients. Drugs Aging. 2000; 17(1):33-51. DOI: 10.2165/00002512-200017010-00003. View

Zhang F, Guo Z, Wu Y, Liu H, Luo Y, Sun M . Prevalence of stroke and associated risk factors: a population based cross sectional study from northeast China. BMJ Open. 2017; 7(9):e015758. PMC: 5589000. DOI: 10.1136/bmjopen-2016-015758. View

Khadka T, Giri G, Mandal D, Shrestha A, Dhungel A, Vaidya A . Multimorbidity in Diabetic Patients Admitted to a Tertiary Care Center: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2023; 61(257):50-53. PMC: 10089050. DOI: 10.31729/jnma.7922. View

Shah S, Shrestha A, Pandey S, Sigdel K, Sah N, Panthi S . Dyslipidemia in Acute Non-cardioembolic Ischemic Stroke Patients at a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2022; 60(247):241-245. PMC: 9226728. DOI: 10.31729/jnma.7321. View

Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M . LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama study. Stroke. 2008; 40(2):382-8. DOI: 10.1161/STROKEAHA.108.529537. View

Feigin V, Lawes C, Bennett D, Barker-Collo S, Parag V . Worldwide stroke incidence and early case fatality reported in 56 population-based studies: a systematic review. Lancet Neurol. 2009; 8(4):355-69. DOI: 10.1016/S1474-4422(09)70025-0. View

10.

Zhang X, Patel A, Horibe H, Wu Z, Barzi F, Rodgers A . Cholesterol, coronary heart disease, and stroke in the Asia Pacific region. Int J Epidemiol. 2003; 32(4):563-72. DOI: 10.1093/ije/dyg106. View

11.

Opoku S, Gan Y, Fu W, Chen D, Addo-Yobo E, Trofimovitch D . Prevalence and risk factors for dyslipidemia among adults in rural and urban China: findings from the China National Stroke Screening and prevention project (CNSSPP). BMC Public Health. 2019; 19(1):1500. PMC: 6849283. DOI: 10.1186/s12889-019-7827-5. View

12.

Kapral M, Fang J, Hill M, Silver F, Richards J, Jaigobin C . Sex differences in stroke care and outcomes: results from the Registry of the Canadian Stroke Network. Stroke. 2005; 36(4):809-14. DOI: 10.1161/01.STR.0000157662.09551.e5. View

13.

Baral S, Pokhrel A, B K S, Kshetri R, Regmi P, Gyawali P . Dyslipidemia among Patients with Ischemic Stroke in the Department of Medicine of a Tertiary Care Centre: A Descriptive Cross-sectional Study. JNMA J Nepal Med Assoc. 2022; 60(250):511-516. PMC: 9275451. DOI: 10.31729/jnma.7491. View

14.

Pyakurel M, Bhattarai S, Joshi B, Koju R, Shrestha A . Burden of Stroke in Nepal: Findings from Global Burden of Disease Dataset 2017. Kathmandu Univ Med J (KUMJ). 2022; 19(75):11-17. View

15.

Donkor E . Stroke in the 21 Century: A Snapshot of the Burden, Epidemiology, and Quality of Life. Stroke Res Treat. 2019; 2018:3238165. PMC: 6288566. DOI: 10.1155/2018/3238165. View

16.

Alloubani A, Nimer R, Samara R . Relationship between Hyperlipidemia, Cardiovascular Disease and Stroke: A Systematic Review. Curr Cardiol Rev. 2020; 17(6):e051121189015. PMC: 8950504. DOI: 10.2174/1573403X16999201210200342. View