Dyslipidemia in Acute Non-cardioembolic Ischemic Stroke Patients at a Tertiary Care Centre: A Descriptive Cross-sectional Study

Overview

Journal JNMA J Nepal Med Assoc

Specialty General Medicine

Date 2022 May 28

PMID 35633254

Authors

Surendra Prasad Shah

Aashish Shrestha

Sirish Raj Pandey

Kaushal Sigdel

Namrata Sah

Sagar Panthi

Lila Bahadur Basnet

Affiliations

Soon will be listed here.

Abstract

Introduction: Acute ischemic stroke is the second most common cause of death after ischemic heart disease worldwide and Nepal's top five diseases based on Disability-Adjusted Life Years. Dyslipidemia is a major risk factor for coronary heart disease but has an unclear role in the pathogenesis of ischemic stroke. The objective of this study was to find the prevalence of dyslipidemia in acute non-cardioembolic ischemic stroke patients at a tertiary care centre.

Methods: A descriptive cross-sectional study was conducted among 76 patients with acute noncardioembolic ischemic stroke admitted in the Neuromedicine unit of a tertiary care centre from August 2017 to July 2018. Ethical approval was obtained from the Institutional Review Committee of the same institute (Reference number: 478/2020). Patients underwent baseline investigations, including fasting lipid profile and Computed Tomography Scan/Magnetic Resonance Imaging head. Data were analysed using Statistical Package for the Social Sciences version 21.0. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.

Results: The prevalence of dyslipidemia among the acute non-cardioembolic ischemic stroke patients was 35 (46.05%) (35.05-57.05 at 95% Confidence Interval) where high total cholesterol was diagnosed in 11 (31.43%), high triglycerides in 25 (71.43%), high low-density-lipoprotein in 10 (28.57%), and low high-density-lipoprotein in 11 (31.43%) patients.

Conclusions: The prevalence of dyslipidemia among acute non-cardioembolic ischemic stroke patients at our tertiary care centre is higher than the similar studies done in similar settings.

Keywords: cardioembolic stroke; dyslipidemia; ischemic stroke; lipid; lipoprotein.

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References

Lisak M, Demarin V, Trkanjec Z, Basic-Kes V . Hypertriglyceridemia as a possible independent risk factor for stroke. Acta Clin Croat. 2014; 52(4):458-63. View

Nordestgaard B . A Test in Context: Lipid Profile, Fasting Versus Nonfasting. J Am Coll Cardiol. 2017; 70(13):1637-1646. DOI: 10.1016/j.jacc.2017.08.006. View

Persky R, Turtzo L, McCullough L . Stroke in women: disparities and outcomes. Curr Cardiol Rep. 2010; 12(1):6-13. PMC: 2861793. DOI: 10.1007/s11886-009-0080-2. View

Curb J, Abbott R, Rodriguez B, Masaki K, Chen R, Popper J . High density lipoprotein cholesterol and the risk of stroke in elderly men: the Honolulu heart program. Am J Epidemiol. 2004; 160(2):150-7. DOI: 10.1093/aje/kwh177. View

Park J, Lee J, Ovbiagele B . Nontraditional serum lipid variables and recurrent stroke risk. Stroke. 2014; 45(11):3269-74. PMC: 4213550. DOI: 10.1161/STROKEAHA.114.006827. View

Kittner S, STERN B, Feeser B, HEBEL R, Nagey D, Buchholz D . Pregnancy and the risk of stroke. N Engl J Med. 1996; 335(11):768-74. PMC: 1479545. DOI: 10.1056/NEJM199609123351102. View

Kurth T, Everett B, Buring J, Kase C, Ridker P, Gaziano J . Lipid levels and the risk of ischemic stroke in women. Neurology. 2007; 68(8):556-62. PMC: 1805634. DOI: 10.1212/01.wnl.0000254472.41810.0d. View

Coupland A, Thapar A, Qureshi M, Jenkins H, Davies A . The definition of stroke. J R Soc Med. 2017; 110(1):9-12. PMC: 5298424. DOI: 10.1177/0141076816680121. View

Olamoyegun M, Akinlade A, Fawale M, Ogbera A . Dyslipidaemia as a risk factor in the occurrence of stroke in Nigeria: prevalence and patterns. Pan Afr Med J. 2017; 25:72. PMC: 5324148. DOI: 10.11604/pamj.2016.25.72.6496. View

10.

Radhiana H, Syazarina S, Shahizon Azura M, Hilwati H, Sobri M . Non-contrast Computed Tomography in Acute Ischaemic Stroke: A Pictorial Review. Med J Malaysia. 2013; 68(1):93-100. View

11.

Carrel L, Willard H . X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature. 2005; 434(7031):400-4. DOI: 10.1038/nature03479. View

12.

Miya Shaik M, Loo K, Gan S . Burden of stroke in Nepal. Int J Stroke. 2012; 7(6):517-20. DOI: 10.1111/j.1747-4949.2012.00799.x. View

13.

. Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002; 106(25):3143-421. View

14.

Freiberg J, Tybjaerg-Hansen A, Skov Jensen J, Nordestgaard B . Nonfasting triglycerides and risk of ischemic stroke in the general population. JAMA. 2008; 300(18):2142-52. DOI: 10.1001/jama.2008.621. View

15.

Imamura T, Doi Y, Arima H, Yonemoto K, Hata J, Kubo M . LDL cholesterol and the development of stroke subtypes and coronary heart disease in a general Japanese population: the Hisayama study. Stroke. 2008; 40(2):382-8. DOI: 10.1161/STROKEAHA.108.529537. View

16.

Ovbiagele B, Nguyen-Huynh M . Stroke epidemiology: advancing our understanding of disease mechanism and therapy. Neurotherapeutics. 2011; 8(3):319-29. PMC: 3250269. DOI: 10.1007/s13311-011-0053-1. View

17.

Amarenco P, Bogousslavsky J, Callahan 3rd A, Goldstein L, Hennerici M, Rudolph A . High-dose atorvastatin after stroke or transient ischemic attack. N Engl J Med. 2006; 355(6):549-59. DOI: 10.1056/NEJMoa061894. View

18.

Sacco R, Benson R, Kargman D, Boden-Albala B, Tuck C, Lin I . High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study. JAMA. 2001; 285(21):2729-35. DOI: 10.1001/jama.285.21.2729. View

19.

Woodward M, Barzi F, Feigin V, Gu D, Huxley R, Nakamura K . Associations between high-density lipoprotein cholesterol and both stroke and coronary heart disease in the Asia Pacific region. Eur Heart J. 2007; 28(21):2653-60. DOI: 10.1093/eurheartj/ehm427. View

20.

Feigin V, Lawes C, Bennett D, Anderson C . Stroke epidemiology: a review of population-based studies of incidence, prevalence, and case-fatality in the late 20th century. Lancet Neurol. 2003; 2(1):43-53. DOI: 10.1016/s1474-4422(03)00266-7. View