Discovery of New Dibenzodiazepine Derivatives As Antibacterials Against Intracellular Bacteria

Overview

Journal RSC Med Chem

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2024 Jan 29

PMID 38283231

Authors

Ling-Han Chen

Man-Yi Lin

Hsueh-Chun Lin

Fan-Wei Yang

Hsiao-Wei Liao

Chung-Wai Shiau

Hao-Chieh Chiu

Jung-Chen Su

Affiliations

Soon will be listed here.

Abstract

The emergence and spread of multidrug-resistant bacteria underscore the critical need for novel antibacterial interventions. In our screening of 12 synthesized thienobenzodiazepines, pyridobenzodiazepines, and dibenzodiazepines, we successfully identified a small molecule compound SW33. Notably, SW33 demonstrated potent inhibitory activity against intracellular multidrug-resistant and fluoroquinolone-resistant strains of in both macrophages and epithelial cells. Furthermore, SW33 was also effective against intramacrophagic , , and . These significant findings suggest that SW33 possesses broad-spectrum activity against intracellular bacteria.

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